Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP)
1_MASDE 6_ GKLFV 11_ GGLSF 16_ DTNEQ 21_ SLEQV 26_ FSKYG 31_ QISEV 36_ VVVKD 41_ RETQR 46_ SRGFG 51_ FVTFE 56_ NIDDA 61_ KDAMM 66_ AMNGK 71_ SVDGR 76_ QIRVD 81_ QAGKS 86_ SDNRS 91_ RGYRG 96_ GSAGG 101_ RGFFR 106_ GGRGR 111_ GRGFS 116_ RGGGD 121_ RGYGG 126_ NRFES 131_ RSGGY 136_ GGSRD 141_ YYSSR 146_ SQSGG 151_ YSDRS 156_ SGGSY 161_ RDSYD 166_SYATH
1: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed