Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha)
1_MLGAV 6_ EGPRW 11_ KQAED 16_ IRDIY 21_ DFRDV 26_ LGTGA 31_ FSEVI 36_ LAEDK 41_ RTQKL 46_ VAIKC 51_ IAKEA 56_ LEGKE 61_ GSMEN 66_ EIAVL 71_ HKIKH 76_ PNIVA 81_ LDDIY 86_ ESGGH 91_ LYLIM 96_ QLVSG 101_ GELFD 106_ RIVEK 111_ GFYTE 116_ RDASR 121_ LIFQV 126_ LDAVK 131_ YLHDL 136_ GIVHR 141_ DLKPE 146_ NLLYY 151_ SLDED 156_ SKIMI 161_ SDFGL 166_ SKMED 171_ PGSVL 176_ STACG 181_ TPGYV 186_ APEVL 191_ AQKPY 196_ SKAVD 201_ CWSIG 206_ VIAYI 211_ LLCGY 216_ PPFYD 221_ ENDAK 226_ LFEQI 231_ LKAEY 236_ EFDSP 241_ YWDDI 246_ SDSAK 251_ DFIRH 256_ LMEKD 261_ PEKRF 266_ TCEQA 271_ LQHPW 276_ IAGDT 281_ ALDKN 286_ IHQSV 291_ SEQIK 296_ KNFAK 301_ SKWKQ 306_ AFNAT 311_ AVVRH 316_ MRKLQ 321_ LGTSQ 326_ EGQGQ 331_ TASHG 336_ ELLTP 341_ VAGGP 346_ AAGCC 351_ CRDCC 356_ VEPGT 361_ELSPT
1: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I