Cyclic nucleotide-gated cation channel beta-1 (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel beta-1) (CNG channel beta-1) (Glutamic acid-rich protein) (GARP)
1_MLGWV 6_ QRVLP 11_ QPPGT 16_ PRKTK 21_ MQEEE 26_ EVEPE 31_ PEMEA 36_ EVEPE 41_ PNPEE 46_ AETES 51_ ESMPP 56_ EESFK 61_ EEEVA 66_ VADPS 71_ PQETK 76_ EAALT 81_ STISL 86_ RAQGA 91_ EISEM 96_ NSPSR 101_ RVLTW 106_ LMKGV 111_ EKVIP 116_ QPVHS 121_ ITEDP 126_ AQILG 131_ HGSTG 136_ DTGCT 141_ DEPNE 146_ ALEAQ 151_ DTRPG 156_ LRLLL 161_ WLEQN 166_ LERVL 171_ PQPPK 176_ SSEVW 181_ RDEPA 186_ VATGA 191_ ASDPA 196_ PPGRP 201_ QEMGP 206_ KLQAR 211_ ETPSL 216_ PTPIP 221_ LQPKE 226_ EPKEA 231_ PAPEP 236_ QPGSQ 241_ AQTSS 246_ LPPTR 251_ DPARL 256_ VAWVL 261_ HRLEM 266_ ALPQP 271_ VLHGK 276_ IGEQE 281_ PDSPG 286_ ICDVQ 291_ TISIL 296_ PGGQV 301_ EPDLV 306_ LEEVE 311_ PPWED 316_ AHQDV 321_ STSPQ 326_ GTEVV 331_ PAYEE 336_ ENKAV 341_ EKMPR 346_ ELSRI 351_ EEEKE 356_ DEEEE 361_ EEEEE 366_ EEEEE 371_ EVTEV 376_ LLDSC 381_ VVSQV 386_ GVGQS 391_ EEDGT 396_ RPQST 401_ SDQKL 406_ WEEVG 411_ EEAKK 416_ EAEEK 421_ AKEEA 426_ EEVAE 431_ EEAEK 436_ EPQDW 441_ AETKE 446_ EPEAE 451_ AEAAS 456_ SGVPA 461_ TKQHP 466_ EVQVE 471_ DTDAD 476_ SCPLM 481_ AEENP 486_ PSTVL 491_ PPPSP 496_ AKSDT 501_ LIVPS 506_ SASGT 511_ HRKKL 516_ PSEDD 521_ EAEEL 526_ KALSP 531_ AESPV 536_ VAWSD 541_ PTTPK 546_ DTDGQ 551_ DRAAS 556_ TASTN 561_ SAIIN 566_ DRLQE 571_ LVKLF 576_ KERTE 581_ KVKEK 586_ LIDPD 591_ VTSDE 596_ ESPKP 601_ SPAKK 606_ APEPA 611_ PDTKP 616_ AEAEP 621_ VEEEH 626_ YCDML 631_ CCKFK 636_ HRPWK 641_ KYQFP 646_ QSIDP 651_ LTNLM 656_ YVLWL 661_ FFVVM 666_ AWNWN 671_ CWLIP 676_ VRWAF 681_ PYQTP 686_ DNIHH 691_ WLLMD 696_ YLCDL 701_ IYFLD 706_ ITVFQ 711_ TRLQF 716_ VRGGD 721_ IITDK 726_ KDMRN 731_ NYLKS 736_ RRFKM 741_ DLLSL 746_ LPLDF 751_ LYLKV 756_ GVNPL 761_ LRLPR 766_ CLKYM 771_ AFFEF 776_ NSRLE 781_ SILSK 786_ AYVYR 791_ VIRTT 796_ AYLLY 801_ SLHLN 806_ SCLYY 811_ WASAY 816_ QGLGS 821_ THWVY 826_ DGVGN 831_ SYIRC 836_ YYFAV 841_ KTLIT 846_ IGGLP 851_ DPKTL 856_ FEIVF 861_ QLLNY 866_ FTGVF 871_ AFSVM 876_ IGQMR 881_ DVVGA 886_ ATAGQ 891_ TYYRS 896_ CMDST 901_ VKYMN 906_ FYKIP 911_ KSVQN 916_ RVKTW 921_ YEYTW 926_ HSQGM 931_ LDESE 936_ LMVQL 941_ PDKMR 946_ LDLAI 951_ DVNYN 956_ IVSKV 961_ ALFQG 966_ CDRQM 971_ IFDML 976_ KRLRS 981_ VVYLP 986_ NDYVC 991_ KKGEI 996_ GREMY 1001_ IIQAG 1006_ QVQVL 1011_ GGPDG 1016_ KSVLV 1021_ TLKAG 1026_ SVFGE 1031_ ISLLA 1036_ VGGGN 1041_ RRTAN 1046_ VVAHG 1051_ FTNLF 1056_ ILDKK 1061_ DLNEI 1066_ LVHYP 1071_ ESQKL 1076_ LRKKA 1081_ RRMLR 1086_ SNNKP 1091_ KEEKS 1096_ VLILP 1101_ PRAGT 1106_ PKLFN 1111_ AALAM 1116_ TGKMG 1121_ GKGAK 1126_ GGKLA 1131_ HLRAR 1136_ LKELA 1141_ ALEAA 1146_ AKQQE 1151_ LVEQA 1156_ KSSQD 1161_ VKGEE 1166_ GSAAP 1171_ DQHTH 1176_ PKEAA 1181_ TDPPA 1186_ PRTPP 1191_ EPPGS 1196_ PPSSP 1201_ PPASL 1206_ GRPEG 1211_ EEEGP 1216_ AEPEE 1221_ HSVRI 1226_ CMSPG 1231_ PEPGE 1236_ QILSV 1241_ KMPEE 1246_REEKA
1: Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade (By similarity) (PubMed:34699778). Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants (By similarity). Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels (By similarity) (PubMed:34699778)
2: High affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit