Bile acid-CoA:amino acid N-acyltransferase (BACAT) (BAT) (EC 2.3.1.65) (Bile acid-CoA thioesterase) (Choloyl-CoA hydrolase) (EC 3.1.2.27) (Glycine N-choloyltransferase) (Long-chain fatty-acyl-CoA hydrolase) (EC 3.1.2.2)
1_MIQLT 6_ ATPVS 11_ ALVDE 16_ PVHIR 21_ ATGLI 26_ PFQMV 31_ SFQAS 36_ LEDEN 41_ GDMFY 46_ SQAHY 51_ RANEF 56_ GEVDL 61_ NHASS 66_ LGGDY 71_ MGVHP 76_ MGLFW 81_ SLKPE 86_ KLLTR 91_ LLKRD 96_ VMNRP 101_ FQVQV 106_ KLYDL 111_ ELIVN 116_ NKVAS 121_ APKAS 126_ LTLER 131_ WYVAP 136_ GVTRI 141_ KVREG 146_ RLRGA 151_ LFLPP 156_ GEGLF 161_ PGVID 166_ LFGGL 171_ GGLLE 176_ FRASL 181_ LASRG 186_ FASLA 191_ LAYHN 196_ YEDLP 201_ RKPEV 206_ TDLEY 211_ FEEAA 216_ NFLLR 221_ HPKVF 226_ GSGVG 231_ VVSVC 236_ QGVQI 241_ GLSMA 246_ IYLKQ 251_ VTATV 256_ LINGT 261_ NFPFG 266_ IPQVY 271_ HGQIH 276_ QPLPH 281_ SAQLI 286_ STNAL 291_ GLLEL 296_ YRTFE 301_ TTQVG 306_ ASQYL 311_ FPIEE 316_ AQGQF 321_ LFIVG 326_ EGDKT 331_ INSKA 336_ HAEQA 341_ IGQLK 346_ RHGKN 351_ NWTLL 356_ SYPGA 361_ GHLIE 366_ PPYSP 371_ LCCAS 376_ TTHDL 381_ RLHWG 386_ GEVIP 391_ HAAAQ 396_ EHAWK 401_ EIQRF 406_ LRKHL 411_IPDVT
1: Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine (PubMed:12239217, PubMed:12810727, PubMed:2037576, PubMed:8034703). More than 95% of the BAs are N-acyl amidates with glycine and taurine (PubMed:8034703). Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (PubMed:12810727). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (PubMed:12810727). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (PubMed:12239217, PubMed:12810727, PubMed:8034703). In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (PubMed:12810727)