Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)
1_MSEEQ 6_ FGGDG 11_ AAAAA 16_ TAAVG 21_ GSAGE 26_ QEGAM 31_ VAATQ 36_ GAAAA 41_ AGSGA 46_ GTGGG 51_ TASGG 56_ TEGGS 61_ AESEG 66_ AKIDA 71_ SKNEE 76_ DEGHS 81_ NSSPR 86_ HSEAA 91_ TAQRE 96_ EWKMF 101_ IGGLS 106_ WDTTK 111_ KDLKD 116_ YFSKF 121_ GEVVD 126_ CTLKL 131_ DPITG 136_ RSRGF 141_ GFVLF 146_ KESES 151_ VDKVM 156_ DQKEH 161_ KLNGK 166_ VIDPK 171_ RAKAM 176_ KTKEP 181_ VKKIF 186_ VGGLS 191_ PDTPE 196_ EKIRE 201_ YFGGF 206_ GEVES 211_ IELPM 216_ DNKTN 221_ KRRGF 226_ CFITF 231_ KEEEP 236_ VKKIM 241_ EKKYH 246_ NVGLS 251_ KCEIK 256_ VAMSK 261_ EQYQQ 266_ QQQWG 271_ SRGGF 276_ AGRAR 281_ GRGGG 286_ PSQNW 291_ NQGYS 296_ NYWNQ 301_ GYGNY 306_ GYNSQ 311_ GYGGY 316_ GGYDY 321_ TGYNN 326_ YYGYG 331_ DYSNQ 336_ QSGYG 341_ KVSRR 346_GGHQN
1: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation