Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)
1_MGLPE 6_ PGPLR 11_ LLALL 16_ LLLLL 21_ LLLLQ 26_ LQHLA 31_ AAAAD 36_ PLLGG 41_ QGPAK 46_ DCEKD 51_ QFQCR 56_ NERCI 61_ PSVWR 66_ CDEDD 71_ DCLDH 76_ SDEDD 81_ CPKKT 86_ CADSD 91_ FTCDN 96_ GHCIH 101_ ERWKC 106_ DGEEE 111_ CPDGS 116_ DESEA 121_ TCTKQ 126_ VCPAE 131_ KLSCG 136_ PTSHK 141_ CVPAS 146_ WRCDG 151_ EKDCE 156_ GGADE 161_ AGCAT 166_ LCAPH 171_ EFQCG 176_ NRSCL 181_ AAVFV 186_ CDGDD 191_ DCGDG 196_ SDERG 201_ CADPA 206_ CGPRE 211_ FRCGG 216_ DGGGA 221_ CIPER 226_ WVCDR 231_ QFDCE 236_ DRSDE 241_ AAELC 246_ GRPGP 251_ GATSA 256_ PAACA 261_ TASQF 266_ ACRSG 271_ ECVHL 276_ GWRCD 281_ GDRDC 286_ KDKSD 291_ EADCP 296_ LGTCR 301_ GDEFQ 306_ CGDGT 311_ CVLAI 316_ KHCNQ 321_ EQDCP 326_ DGSDE 331_ AGCLQ 336_ GLNEC 341_ LHNNG 346_ GCSHI 351_ CTDLK 356_ IGFEC 361_ TCPAG 366_ FQLLD 371_ QKTCG 376_ DIDEC 381_ KDPDA 386_ CSQIC 391_ VNYKG 396_ YFKCE 401_ CYPGY 406_ EMDLL 411_ TKNCK 416_ AAAGK 421_ SPSLI 426_ FTNRH 431_ EVRRI 436_ DLVKR 441_ NYSRL 446_ IPMLK 451_ NVVAL 456_ DVEVA 461_ TNRIY 466_ WCDLS 471_ YRKIY 476_ SAYMD 481_ KASDP 486_ KEQEV 491_ LIDEQ 496_ LHSPE 501_ GLAVD 506_ WVHKH 511_ IYWTD 516_ SGNKT 521_ ISVAT 526_ VDGGR 531_ RRTLF 536_ SRNLS 541_ EPRAI 546_ AVDPL 551_ RGFMY 556_ WSDWG 561_ DQAKI 566_ EKSGL 571_ NGVDR 576_ QTLVS 581_ DNIEW 586_ PNGIT 591_ LDLLS 596_ QRLYW 601_ VDSKL 606_ HQLSS 611_ IDFSG 616_ GNRKT 621_ LISST 626_ DFLSH 631_ PFGIA 636_ VFEDK 641_ VFWTD 646_ LENEA 651_ IFSAN 656_ RLNGL 661_ EISIL 666_ AENLN 671_ NPHDI 676_ VIFHE 681_ LKQPR 686_ APDAC 691_ ELSVQ 696_ PNGGC 701_ EYLCL 706_ PAPQI 711_ SSHSP 716_ KYTCA 721_ CPDTM 726_ WLGPD 731_ MKRCY 736_ RAPQS 741_ TSTTT 746_ LASTM 751_ TRTVP 756_ ATTRA 761_ PGTTV 766_ HRSTY 771_ QNHST 776_ ETPSL 781_ TAAVP 786_ SSVSV 791_ PRAPS 796_ ISPST 801_ LSPAT 806_ SNHSQ 811_ HYANE 816_ DSKMG 821_ STVTA 826_ AVIGI 831_ IVPIV 836_ VIALL 841_ CMSGY 846_ LIWRN 851_ WKRKN 856_ TKSMN 861_ FDNPV 866_ YRKTT 871_ EEEDE 876_ DELHI 881_ GRTAQ 886_ IGHVY 891_ PAAIS 896_ SFDRP 901_ LWAEP 906_ CLGET 911_ REPED 916_ PAPAL 921_ KELFV 926_ LPGEP 931_ RSQLH 936_ QLPKN 941_ PLSEL 946_ PVVKS 951_ KRVAL 956_SLEDD
1: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands (PubMed:12899622, PubMed:12950167, PubMed:20223215, PubMed:30873003). LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail (By similarity). Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons (By similarity). LRP8 has higher affinity for Reelin than VLDLR (By similarity). LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development (By similarity). Binds the endoplasmic reticulum resident receptor-associated protein (RAP) (By similarity). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature (PubMed:12807892). Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation (By similarity). May also function as an endocytic receptor (By similarity). Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity)
2: (Microbial infection) Acts as a receptor for Semliki Forest virus