Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
1_MAAEP 6_ VEDNC 11_ INFVA 16_ MKFID 21_ NTLYF 26_ IAEDD 31_ ENLES 36_ DYFGK 41_ LESKL 46_ SVIRN 51_ LNDQV 56_ LFIDQ 61_ GNRPL 66_ FEDMT 71_ DSDCR 76_ DNAPR 81_ TIFII 86_ SMYKD 91_ SQPRG 96_ MAVTI 101_ SVKCE 106_ KISTL 111_ SCENK 116_ IISFK 121_ EMNPP 126_ DNIKD 131_ TKSDI 136_ IFFQR 141_ SVPGH 146_ DNKMQ 151_ FESSS 156_ YEGYF 161_ LACEK 166_ ERDLF 171_ KLILK 176_ KEDEL 181_ GDRSI 186_MFTVQ
1: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532, PubMed:37993714). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744)