Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]
1_MRMSV 6_ GLSLL 11_ LPLSG 16_ RTFLL 21_ LLSVV 26_ MAQSH 31_ WPSEP 36_ SEAVR 41_ DWENQ 46_ LEASM 51_ HSVLS 56_ DLHEA 61_ VPTVV 66_ GIPDG 71_ TAVVG 76_ RSFRV 81_ TIPTD 86_ LIASS 91_ GDIIK 96_ VSAAG 101_ KEALP 106_ SWLHW 111_ DSQSH 116_ TLEGL 121_ PLDTD 126_ KGVHY 131_ ISVSA 136_ TRLGA 141_ NGSHI 146_ PQTSS 151_ VFSIE 156_ VYPED 161_ HSELQ 166_ SVRTA 171_ SPDPG 176_ EVVSS 181_ ACAAD 186_ EPVTV 191_ LTVIL 196_ DADLT 201_ KMTPK 206_ QRIDL 211_ LHRMR 216_ SFSEV 221_ ELHNM 226_ KLVPV 231_ VNNRL 236_ FDMSA 241_ FMAGP 246_ GNAKK 251_ VVENG 256_ ALLSW 261_ KLGCS 266_ LNQNS 271_ VPDIH 276_ GVEAP 281_ AREGA 286_ MSAQL 291_ GYPVV 296_ GWHIA 301_ NKKPP 306_ LPKRV 311_ RRQIH 316_ ATPTP 321_ VTAIG 326_ PPTTA 331_ IQEPP 336_ SRIVP 341_ TPTSP 346_ AIAPP 351_ TETMA 356_ PPVRD 361_ PVPGK 366_ PTVTI 371_ RTRGA 376_ IIQTP 381_ TLGPI 386_ QPTRV 391_ SEAGT 396_ TVPGQ 401_ IRPTM 406_ TIPGY 411_ VEPTA 416_ VATPP 421_ TTTTK 426_ KPRVS 431_ TPKPA 436_ TPSTD 441_ STTTT 446_ TRRPT 451_ KKPRT 456_ PRPVP 461_ RVTTK 466_ VSITR 471_ LETAS 476_ PPTRI 481_ RTTTS 486_ GVPRG 491_ GEPNQ 496_ RPELK 501_ NHIDR 506_ VDAWV 511_ GTYFE 516_ VKIPS 521_ DTFYD 526_ HEDTT 531_ TDKLK 536_ LTLKL 541_ REQQL 546_ VGEKS 551_ WVQFN 556_ SNSQL 561_ MYGLP 566_ DSSHV 571_ GKHEY 576_ FMHAT 581_ DKGGL 586_ SAVDA 591_ FEIHV 596_ HRRPQ 601_ GDRAP 606_ ARFKA 611_ KFVGD 616_ PALVL 621_ NDIHK 626_ KIALV 631_ KKLAF 636_ AFGDR 641_ NCSTI 646_ TLQNI 651_ TRGSI 656_ VVEWT 661_ NNTLP 666_ LEPCP 671_ KEQIA 676_ GLSRR 681_ IAEDD 686_ GKPRP 691_ AFSNA 696_ LEPDF 701_ KATSI 706_ TVTGS 711_ GSCRH 716_ LQFIP 721_ VVPPR 726_ RVPSE 731_ APPTE 736_ VPDRD 741_ PEKSS 746_ EDDVY 751_ LHTVI 756_ PAVVV 761_ AAILL 766_ IAGII 771_ AMICY 776_ RKKRK 781_ GKLTL 786_ EDQAT 791_ FIKKG 796_ VPIIF 801_ ADELD 806_ DSKPP 811_ PSSSM 816_ PLILQ 821_ EEKAP 826_ LPPPE 831_ YPNQS 836_ VPETT 841_ PLNQD 846_ TMGEY 851_ TPLRD 856_ EDPNA 861_ PPYQP 866_ PPPFT 871_ APMEG 876_ KGSRP 881_ KNMTP 886_YRSPP
1: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization
2: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity)
3: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity
4: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:17360738, PubMed:19324387). Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927)