Dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3)
1_MESPT 6_ KEIEE 11_ FESNS 16_ LKYLQ 21_ PEQIE 26_ KIWLR 31_ LRGLR 36_ KYKKT 41_ SQRLR 46_ SLVKQ 51_ LERGE 56_ ASVVD 61_ LKKNL 66_ EYAAT 71_ VLESV 76_ YIDET 81_ RRLLD 86_ TEDEL 91_ SDIQS 96_ DAVPS 101_ EVRDW 106_ LASTF 111_ TRQMG 116_ MMLRR 121_ SDEKP 126_ RFKSI 131_ VHAVQ 136_ AGIFV 141_ ERMYR 146_ RTSNM 151_ VGLSY 156_ PPAVI 161_ EALKD 166_ VDKWS 171_ FDVFS 176_ LNEAS 181_ GDHAL 186_ KFIFY 191_ ELLTR 196_ YDLIS 201_ RFKIP 206_ ISALV 211_ SFVEA 216_ LEVGY 221_ SKHKN 226_ PYHNL 231_ MHAAD 236_ VTQTV 241_ HYLLY 246_ KTGVA 251_ NWLTE 256_ LEIFA 261_ IIFSA 266_ AIHDY 271_ EHTGT 276_ TNNFH 281_ IQTRS 286_ DPAIL 291_ YNDRS 296_ VLENH 301_ HLSAA 306_ YRLLQ 311_ DDEEM 316_ NILIN 321_ LSKDD 326_ WREFR 331_ TLVIE 336_ MVMAT 341_ DMSCH 346_ FQQIK 351_ AMKTA 356_ LQQPE 361_ AIEKP 366_ KALSL 371_ MLHTA 376_ DISHP 381_ AKAWD 386_ LHHRW 391_ TMSLL 396_ EEFFR 401_ QGDRE 406_ AELGL 411_ PFSPL 416_ CDRKS 421_ TMVAQ 426_ SQVGF 431_ IDFIV 436_ EPTFT 441_ VLTDM 446_ TEKIV 451_ SPLID 456_ ETSQT 461_ GGTGQ 466_ RRSSL 471_ NSISS 476_ SDAKR 481_ SGVKT 486_ SGSEG 491_ SAPIN 496_ NSVIS 501_ VDYKS 506_ FKATW 511_ TEVVH 516_ INRER 521_ WRAKV 526_ PKEEK 531_ AKKEA 536_ EEKAR 541_ LAAEE 546_ QQKEM 551_ EAKSQ 556_ AEEGA 561_ SGKAE 566_ KKTSG 571_ ETKNQ 576_ VNGTR 581_ ANKSD 586_ NPRGK 591_ NSKAE 596_ KSSGE 601_ QQQNG 606_ DFKDG 611_ KNKTD 616_ KKDHS 621_ NIGND 626_ SKKTD 631_ GTKQR 636_ SHGSP 641_ APSTS 646_ STCRL 651_ TLPVI 656_ KPPLR 661_ HFKRP 666_ AYASS 671_ SYAPS 676_ VSKKT 681_ DEHPA 686_ RYKML 691_ DQRIK 696_ MKKIQ 701_NISHN
1: Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:29860631, PubMed:8557689). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable)