Desmoglein-2 (Cadherin family member 5) (HDGC)
1_MARSP 6_ GRAYA 11_ LLLLL 16_ ICFNV 21_ GSGLH 26_ LQVLS 31_ TRNEN 36_ KLLPK 41_ HPHLV 46_ RQKRA 51_ WITAP 56_ VALRE 61_ GEDLS 66_ KKNPI 71_ AKIHS 76_ DLAEE 81_ RGLKI 86_ TYKYT 91_ GKGIT 96_ EPPFG 101_ IFVFN 106_ KDTGE 111_ LNVTS 116_ ILDRE 121_ ETPFF 126_ LLTGY 131_ ALDAR 136_ GNNVE 141_ KPLEL 146_ RIKVL 151_ DINDN 156_ EPVFT 161_ QDVFV 166_ GSVEE 171_ LSAAH 176_ TLVMK 181_ INATD 186_ ADEPN 191_ TLNSK 196_ ISYRI 201_ VSLEP 206_ AYPPV 211_ FYLNK 216_ DTGEI 221_ YTTSV 226_ TLDRE 231_ EHSSY 236_ TLTVE 241_ ARDGN 246_ GEVTD 251_ KPVKQ 256_ AQVQI 261_ RILDV 266_ NDNIP 271_ VVENK 276_ VLEGM 281_ VEENQ 286_ VNVEV 291_ TRIKV 296_ FDADE 301_ IGSDN 306_ WLANF 311_ TFASG 316_ NEGGY 321_ FHIET 326_ DAQTN 331_ EGIVT 336_ LIKEV 341_ DYEEM 346_ KNLDF 351_ SVIVA 356_ NKAAF 361_ HKSIR 366_ SKYKP 371_ TPIPI 376_ KVKVK 381_ NVKEG 386_ IHFKS 391_ SVISI 396_ YVSES 401_ MDRSS 406_ KGQII 411_ GNFQA 416_ FDEDT 421_ GLPAH 426_ ARYVK 431_ LEDRD 436_ NWISV 441_ DSVTS 446_ EIKLA 451_ KLPDF 456_ ESRYV 461_ QNGTY 466_ TVKIV 471_ AISED 476_ YPRKT 481_ ITGTV 486_ LINVE 491_ DINDN 496_ CPTLI 501_ EPVQT 506_ ICHDA 511_ EYVNV 516_ TAEDL 521_ DGHPN 526_ SGPFS 531_ FSVID 536_ KPPGM 541_ AEKWK 546_ IARQE 551_ STSVL 556_ LQQSE 561_ KKLGR 566_ SEIQF 571_ LISDN 576_ QGFSC 581_ PEKQV 586_ LTLTV 591_ CECLH 596_ GSGCR 601_ EAQHD 606_ SYVGL 611_ GPAAI 616_ ALMIL 621_ AFLLL 626_ LLVPL 631_ LLLMC 636_ HCGKG 641_ AKGFT 646_ PIPGT 651_ IEMLH 656_ PWNNE 661_ GAPPE 666_ DKVVP 671_ SFLPV 676_ DQGGS 681_ LVGRN 686_ GVGGM 691_ AKEAT 696_ MKGSS 701_ SASIV 706_ KGQHE 711_ MSEMD 716_ GRWEE 721_ HRSLL 726_ SGRAT 731_ QFTGA 736_ TGAIM 741_ TTETT 746_ KTARA 751_ TGASR 756_ DMAGA 761_ QAAAV 766_ ALNEE 771_ FLRNY 776_ FTDKA 781_ ASYTE 786_ EDENH 791_ TAKDC 796_ LLVYS 801_ QEETE 806_ SLNAS 811_ IGCCS 816_ FIEGE 821_ LDDRF 826_ LDDLG 831_ LKFKT 836_ LAEVC 841_ LGQKI 846_ DINKE 851_ IEQRQ 856_ KPATE 861_ TSMNT 866_ ASHSL 871_ CEQTM 876_ VNSEN 881_ TYSSG 886_ SSFPV 891_ PKSLQ 896_ EANAE 901_ KVTQE 906_ IVTER 911_ SVSSR 916_ QAQKV 921_ ATPLP 926_ DPMAS 931_ RNVIA 936_ TETSY 941_ VTGST 946_ MPPTT 951_ VILGP 956_ SQPQS 961_ LIVTE 966_ RVYAP 971_ ASTLV 976_ DQPYA 981_ NEGTV 986_ VVTER 991_ VIQPH 996_ GGGSN 1001_ PLEGT 1006_ QHLQD 1011_ VPYVM 1016_ VRERE 1021_ SFLAP 1026_ SSGVQ 1031_ PTLAM 1036_ PNIAV 1041_ GQNVT 1046_ VTERV 1051_ LAPAS 1056_ TLQSS 1061_ YQIPT 1066_ ENSMT 1071_ ARNTT 1076_ VSGAG 1081_ VPGPL 1086_ PDFGL 1091_ EESGH 1096_ SNSTI 1101_ TTSST 1106_ RVTKH 1111_STVQH
1: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410)