Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein)
1_MEAAD 6_ ASRSN 11_ GSSPE 16_ ARDAR 21_ SPSGP 26_ SGSLE 31_ NGTKA 36_ DGKDA 41_ KTTNG 46_ HGGEA 51_ AEGKS 56_ LGSAL 61_ KPGEG 66_ RSALF 71_ AGNEW 76_ RRPII 81_ QFVES 86_ GDDKN 91_ SNYFS 96_ MDSME 101_ GKRSP 106_ YAGLQ 111_ LGAAK 116_ KPPVT 121_ FAEKG 126_ ELRKS 131_ IFSES 136_ RKPTV 141_ SIMEP 146_ GETRR 151_ NSYPR 156_ ADTGL 161_ FSRSK 166_ SGSEE 171_ VLCDS 176_ CIGNK 181_ QKAVK 186_ SCLVC 191_ QASFC 196_ ELHLK 201_ PHLEG 206_ AAFRD 211_ HQLLE 216_ PIRDF 221_ EARKC 226_ PVHGK 231_ TMELF 236_ CQTDQ 241_ TCICY 246_ LCMFQ 251_ EHKNH 256_ STVTV 261_ EEAKA 266_ EKETE 271_ LSLQK 276_ EQLQL 281_ KIIEI 286_ EDEAE 291_ KWQKE 296_ KDRIK 301_ SFTTN 306_ EKAIL 311_ EQNFR 316_ DLVRD 321_ LEKQK 326_ EEVRA 331_ ALEQR 336_ EQDAV 341_ DQVKV 346_ IMDAL 351_ DERAK 356_ VLHED 361_ KQTRE 366_ QLHSI 371_ SDSVL 376_ FLQEF 381_ GALMS 386_ NYSLP 391_ PPLPT 396_ YHVLL 401_ EGEGL 406_ GQSLG 411_ NFKDD 416_ LLNVC 421_ MRHVE 426_ KMCKA 431_ DLSRN 436_ FIERN 441_ HMENG 446_ GDHRY 451_ VNNYT 456_ NSFGG 461_ EWSAP 466_ DTMKR 471_ YSMYL 476_ TPKGG 481_ VRTSY 486_ QPSSP 491_ GRFTK 496_ ETTQK 501_ NFNNL 506_ YGTKG 511_ NYTSR 516_ VWEYS 521_ SSIQN 526_ SDNDL 531_ PVVQG 536_ SSSFS 541_ LKGYP 546_ SLMRS 551_ QSPKA 556_ QPQTW 561_ KSGKQ 566_ TMLSH 571_ YRPFY 576_ VNKGN 581_GIGSN
1: Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation