Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A)
1_MTDQE 6_ NNNNI 11_ SSNPF 16_ AALFG 21_ SLADA 26_ KQFAA 31_ IQKEQ 36_ LKQQS 41_ DELPA 46_ SPDDS 51_ DNSVS 56_ ESLDE 61_ FDYSV 66_ AEISR 71_ SFRSQ 76_ QEICE 81_ QLNIN 86_ HMIQR 91_ IFLIT 96_ LDNSD 101_ PSLKS 106_ GNGIP 111_ SRCVY 116_ LEEMA 121_ VELED 126_ QDWLD 131_ MSNVE 136_ QALFA 141_ RLLLQ 146_ DPGNH 151_ LINMT 156_ SSTTL 161_ NLSAD 166_ RDAGE 171_ RHIFC 176_ YLYSC 181_ FQRAK 186_ EEITK 191_ VPENL 196_ LPFAV 201_ QCRNL 206_ TVSNT 211_ RTVLL 216_ TPEIY 221_ VDQNI 226_ HEQLV 231_ DLMLE 236_ AIQGA 241_ HFEDV 246_ TEFLE 251_ EVIEA 256_ LILDE 261_ EVRTF 266_ PEVMI 271_ PVFDI 276_ LLGRI 281_ KDLEL 286_ CQILL 291_ YAYLD 296_ ILLYF 301_ TRQKD 306_ MAKVF 311_ VEYIQ 316_ PKDPT 321_ NGQMY 326_ QKTLL 331_ GVILS 336_ ISCLL 341_ KTPGV 346_ VENHG 351_ YFLNP 356_ SRSSP 361_ QEIKV 366_ QEANI 371_ HQFMA 376_ QFHEK 381_ IYQML 386_ KNLLQ 391_ LSPET 396_ KHCIL 401_ SWLGN 406_ CLHAN 411_ AGRTK 416_ IWANQ 421_ MPEIF 426_ FQMYA 431_ SDAFF 436_ LNLGA 441_ ALLKL 446_ CQPFC 451_ KPRSS 456_ RLLTF 461_ NPTYC 466_ ALKEL 471_ NDEER 476_ KIKNV 481_ HMRGL 486_ DKETC 491_ LIPAV 496_ QEPKF 501_ PQNYN 506_ LVTEN 511_ LALTE 516_ YTLYL 521_ GFHRL 526_ HDQMV 531_ KINQN 536_ LHRLQ 541_ VAWRD 546_ AQQSS 551_ SPAAD 556_ NLREQ 561_ FERLM 566_ TIYLS 571_ TKTAM 576_ TEPQM 581_ LQNCL 586_ NLQVS 591_ MAVLL 596_ VQLAI 601_ GNEGS 606_ QPIEL 611_ TFPLP 616_ DGYSS 621_ LAYVP 626_ EFFAD 631_ NLGDF 636_ LIFLR 641_ RFADD 646_ ILETS 651_ ADSLE 656_ HVLHF 661_ ITIFT 666_ GSIER 671_ MKNPH 676_ LRAKL 681_ AEVLE 686_ AVMPH 691_ LDQTP 696_ NPLVS 701_ SVFHR 706_ KRVFC 711_ NFQYA 716_ PQLAE 721_ ALIKV 726_ FVDIE 731_ FTGDP 736_ HQFEQ 741_ KFNYR 746_ RPMYP 751_ ILRYM 756_ WGTDT 761_ YRESI 766_ KDLAD 771_ YASKN 776_ LEAMN 781_ PPLFL 786_ RFLNL 791_ LMNDA 796_ IFLLD 801_ EAIQY 806_ LSKIK 811_ IQQIE 816_ KDRGE 821_ WDSLT 826_ PEARR 831_ EKEAG 836_ LQMFG 841_ QLARF 846_ HNIMS 851_ NETIG 856_ TLAFL 861_ TSEIK 866_ SLFVH 871_ PFLAE 876_ RIISM 881_ LNYFL 886_ QHLVG 891_ PKMGA 896_ LKVKD 901_ FSEFD 906_ FKPQQ 911_ LVSDI 916_ CTIYL 921_ NLGDE 926_ ENFCA 931_ TVPKD 936_ GRSYS 941_ PTLFA 946_ QTVRV 951_ LKKIN 956_ KPGNM 961_ IMAFS 966_ NLAER 971_ IKSLA 976_ DLQQQ 981_ EEETY 986_ ADACD 991_ EFLDP 996_ IMSTL 1001_ MCDPV 1006_ VLPSS 1011_ RVTVD 1016_ RSTIA 1021_ RHLLS 1026_ DQTDP 1031_ FNRSP 1036_ LTMDQ 1041_ IRPNT 1046_ ELKEK 1051_ IQRWL 1056_ AERKQ 1061_QKEQL
1: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates