SERTA domain-containing protein 2 (Transcriptional regulator interacting with the PHD-bromodomain 2) (TRIP-Br2)
1_MLGKG 6_ GKRKF 11_ DEHED 16_ GLEGK 21_ IVSPC 26_ DGPSK 31_ VSYTL 36_ QRQTI 41_ FNISL 46_ MKLYN 51_ HRPLT 56_ EPSLQ 61_ KTVLI 66_ NNMLR 71_ RIQEE 76_ LKQEG 81_ SLRPM 86_ FTPSS 91_ QPTTE 96_ PSDSY 101_ REAPP 106_ AFSHL 111_ ASPSS 116_ HPCDL 121_ GSTTP 126_ LEACL 131_ TPASL 136_ LEDDD 141_ DTFCT 146_ SQAMQ 151_ PTAPT 156_ KLSPP 161_ ALLPE 166_ KDSFS 171_ SALDE 176_ IEELC 181_ PTSTS 186_ TEAAT 191_ AATDS 196_ VKGTS 201_ SEAGT 206_ QKLDG 211_ PQESR 216_ ADDSK 221_ LMDSL 226_ PGNFE 231_ ITTST 236_ GFLTD 241_ LTLDD 246_ ILFAD 251_ IDTSM 256_ YDFDP 261_ CTSSS 266_ GTASK 271_ MAPVS 276_ ADDLL 281_ KTLAP 286_ YSSQP 291_ VTPSQ 296_ PFKMD 301_ LTELD 306_HIMEV
1: Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism