Tripartite motif-containing protein 14
1_MAGAA 6_ TGSRT 11_ PGRSE 16_ LVEGC 21_ GWRCP 26_ EHGDR 31_ VAELF 36_ CRRCR 41_ RCVCA 46_ LCPVL 51_ GAHRG 56_ HPVGL 61_ ALEAA 66_ VHVQK 71_ LSQEC 76_ LKQLA 81_ IKKQQ 86_ HIDNI 91_ TQIED 96_ ATEKL 101_ KANAE 106_ SSKTW 111_ LKGKF 116_ TELRL 121_ LLDEE 126_ EALAK 131_ KFIDK 136_ NTQLT 141_ LQVYR 146_ EQADS 151_ CREQL 156_ DIMND 161_ LSNRV 166_ WSISQ 171_ EPDPV 176_ QRLQA 181_ YTATE 186_ QEMQQ 191_ QMSLG 196_ ELCHP 201_ VPLSF 206_ EPVKS 211_ FFKGL 216_ VEAVE 221_ STLQT 226_ PLDIR 231_ LKESI 236_ NCQLS 241_ DPSST 246_ KPGTL 251_ LKTSP 256_ SPERS 261_ LLLKY 266_ ARTPT 271_ LDPDT 276_ MHARL 281_ RLSAD 286_ RLTVR 291_ CGLLG 296_ SLGPV 301_ PVLRF 306_ DALWQ 311_ VLARD 316_ CFATG 321_ RHYWE 326_ VDVQE 331_ AGAGW 336_ WVGAA 341_ YASLR 346_ RRGAS 351_ AAARL 356_ GCNRQ 361_ SWCLK 366_ RYDLE 371_ YWAFH 376_ DGQRS 381_ RLRPR 386_ DDLDR 391_ LGVFL 396_ DYEAG 401_ VLAFY 406_ DVTGG 411_ MSHLH 416_ TFRAT 421_ FQEPL 426_ YPALR 431_ LWEGA 436_ISIPR
1: Plays an essential role in the innate immune defense against viruses and bacteria (PubMed:30150992, PubMed:32404352). Promotes the 'Lys-48'-linked ubiquitination and subsequent degradation of hepatitis C virus NS5A leading to the inhibition of viral replication (PubMed:27578425). Also plays a role in the inhibition of ebolavirus infection by enhancing IFN-beta and NF-kappa-B activation after binding to the viral protein NP (PubMed:37562033). Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373). Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593). Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression (PubMed:32404352). Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (By similarity). Also inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3. Mechanistically, recruits USP14 to remove the 'Lys-63'-linked ubiquitination of KDM4D, preventing its recognition by OPTN and subsequent degradation (PubMed:35145029)