Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) (DExH-box helicase 34)
1_MPPPR 6_ TREGR 11_ DRRDH 16_ HRAPS 21_ EEEAL 26_ EKWDW 31_ NCPET 36_ RRLLE 41_ DAFFR 46_ EEDYI 51_ RQGSE 56_ ECQKF 61_ WTFFE 66_ RLQRF 71_ QNLKT 76_ SRKEE 81_ KDPGQ 86_ PKHSI 91_ PALAD 96_ LPRTY 101_ DPRYR 106_ INLSV 111_ LGPAT 116_ RGSQG 121_ LGRHL 126_ PAERV 131_ AEFRR 136_ ALLHY 141_ LDFGQ 146_ KQAFG 151_ RLAKL 156_ QRERA 161_ ALPIA 166_ QYGNR 171_ ILQTL 176_ KEHQV 181_ VVVAG 186_ DTGCG 191_ KSTQV 196_ PQYLL 201_ AAGFS 206_ HVACT 211_ QPRRI 216_ ACISL 221_ AKRVG 226_ FESLS 231_ QYGSQ 236_ VGYQI 241_ RFEST 246_ RSAAT 251_ KIVFL 256_ TVGLL 261_ LRQIQ 266_ REPSL 271_ PQYEV 276_ LIVDE 281_ VHERH 286_ LHNDF 291_ LLGVL 296_ QRLLP 301_ TRPDL 306_ KVILM 311_ SATIN 316_ ISLFS 321_ SYFSN 326_ APVVQ 331_ VPGRL 336_ FPITV 341_ VYQPQ 346_ EAEPT 351_ TSKSE 356_ KLDPR 361_ PFLRV 366_ LESID 371_ HKYPP 376_ EERGD 381_ LLVFL 386_ SGMAE 391_ ISAVL 396_ EAAQT 401_ YASHT 406_ QRWVV 411_ LPLHS 416_ ALSVA 421_ DQDKV 426_ FDVAP 431_ PGVRK 436_ CILST 441_ NIAET 446_ SVTID 451_ GIRFV 456_ VDSGK 461_ VKEMS 466_ YDPQA 471_ KLQRL 476_ QEFWI 481_ SQASA 486_ EQRKG 491_ RAGRT 496_ GPGVC 501_ FRLYA 506_ ESDYD 511_ AFAPY 516_ PVPEI 521_ RRVAL 526_ DSLVL 531_ QMKSM 536_ SVGDP 541_ RTFPF 546_ IEPPP 551_ PASLE 556_ TAILY 561_ LRDQG 566_ ALDSS 571_ EALTP 576_ IGSLL 581_ AQLPV 586_ DVVIG 591_ KMLIL 596_ GSMFS 601_ LVEPV 606_ LTIAA 611_ ALSVQ 616_ SPFTR 621_ SAQSS 626_ PECAA 631_ ARRPL 636_ ESDQG 641_ DPFTL 646_ FNVFN 651_ AWVQV 656_ KSERS 661_ RNSRK 666_ WCRRR 671_ GIEEH 676_ RLYEM 681_ ANLRR 686_ QFKEL 691_ LEDHG 696_ LLAGA 701_ QAAQV 706_ GDSYS 711_ RLQQR 716_ RERRA 721_ LHQLK 726_ RQHEE 731_ GAGRR 736_ RKVLR 741_ LQEEQ 746_ DGGSS 751_ DEDRA 756_ GPAPP 761_ GASDG 766_ VDIQD 771_ VKFKL 776_ RHDLA 781_ QLQAA 786_ ASSAQ 791_ DLSRE 796_ QLALL 801_ KLVLG 806_ RGLYP 811_ QLAVP 816_ DAFNS 821_ SRKDS 826_ DQIFH 831_ TQAKQ 836_ GAVLH 841_ PTCVF 846_ AGSPE 851_ VLHAQ 856_ ELEAS 861_ NCDGS 866_ RDDKD 871_ KMSSK 876_ HQLLS 881_ FVSLL 886_ ETNKP 891_ YLVNC 896_ VRIPA 901_ LQSLL 906_ LFSRS 911_ LDTNG 916_ DCSRL 921_ VADGW 926_ LELQL 931_ ADSES 936_ AIRLL 941_ AASLR 946_ LRARW 951_ ESALD 956_ RQLAH 961_ QAQQQ 966_ LEEEE 971_ EDTPV 976_ SPKEV 981_ ATLSK 986_ ELLQF 991_ TASKI 996_ PYSLR 1001_ RLTGL 1006_ EVQNM 1011_ YVGPQ 1016_ TIPAT 1021_ PHLPG 1026_ LFGSS 1031_ TLSPH 1036_ PTKGG 1041_ YAVTD 1046_ FLTYN 1051_ CLTND 1056_ TDLYS 1061_ DCLRT 1066_ FWTCP 1071_ HCGLH 1076_ APLTP 1081_ LERIA 1086_ HENTC 1091_ PQAPQ 1096_ DGPPG 1101_ AEEAA 1106_ LETLQ 1111_ KTSVL 1116_ QRPYH 1121_ CEACG 1126_ KDFLF 1131_ TPTEV 1136_LRHRK
1: Probable ATP-binding RNA helicase required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons (PubMed:25220460, PubMed:33205750). Promotes the phosphorylation of UPF1 along with its interaction with key NMD pathway proteins UPF2 and EIF4A3 (PubMed:25220460). Interaction with the RUVBL1-RUVBL2 complex results in loss of nucleotide binding ability and ATP hydrolysis of the complex (PubMed:33205750). Negatively regulates the nucleotide binding ability and ATP hydrolysis of the RUVBL1-RUVBL2 complex via induction of N-terminus conformation changes of the RUVBL2 subunits (PubMed:33205750)