MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3)
1_MAAQP 6_ PRGIR 11_ LSALC 16_ PKFLH 21_ TNSTS 26_ HTWPF 31_ SAVAE 36_ LIDNA 41_ YDPDV 46_ NAKQI 51_ WIDKT 56_ VINDH 61_ ICLTF 66_ TDNGN 71_ GMTSD 76_ KLHKM 81_ LSFGF 86_ SDKVT 91_ MNGHV 96_ PVGLY 101_ GNGFK 106_ SGSMR 111_ LGKDA 116_ IVFTK 121_ NGESM 126_ SVGLL 131_ SQTYL 136_ EVIKA 141_ EHVVV 146_ PIVAF 151_ NKHRQ 156_ MINLA 161_ ESKAS 166_ LAAIL 171_ EHSLF 176_ STEQK 181_ LLAEL 186_ DAIIG 191_ KKGTR 196_ IIIWN 201_ LRSYK 206_ NATEF 211_ DFEKD 216_ KYDIR 221_ IPEDL 226_ DEITG 231_ KKGYK 236_ KQERM 241_ DQIAP 246_ ESDYS 251_ LRAYC 256_ SILYL 261_ KPRMQ 266_ IILRG 271_ QKVKT 276_ QLVSK 281_ SLAYI 286_ ERDVY 291_ RPKFL 296_ SKTVR 301_ ITFGF 306_ NCRNK 311_ DHYGI 316_ MMYHR 321_ NRLIK 326_ AYEKV 331_ GCQLR 336_ ANNMG 341_ VGVVG 346_ IIECN 351_ FLKPT 356_ HNKQD 361_ FDYTN 366_ EYRLT 371_ ITALG 376_ EKLND 381_ YWNEM 386_ KVKKN 391_ TEYPL 396_ NLPVE 401_ DIQKR 406_ PDQTW 411_ VQCDA 416_ CLKWR 421_ KLPDG 426_ MDQLP 431_ EKWYC 436_ SNNPD 441_ PQFRN 446_ CEVPE 451_ EPEDE 456_ DLVHP 461_ TYEKT 466_ YKKTN 471_ KEKFR 476_ IRQPE 481_ MIPRI 486_ NAELL 491_ FRPTA 496_ LSTPS 501_ FSSPK 506_ ESVPR 511_ RHLSE 516_ GTNSY 521_ ATRLL 526_ NNHQV 531_ PPQSE 536_ PESNS 541_ LKRRL 546_ STRSS 551_ ILNAK 556_ NRRLS 561_ SQFEN 566_ SVYKG 571_ DDDDE 576_ DVIIL 581_ EENST 586_ PKPAV 591_ DHDID 596_ MKSEQ 601_ SHVEQ 606_ GGVQV 611_ EFVGD 616_ SEPCG 621_ QTGST 626_ STSSS 631_ RCDQG 636_ NTAAT 641_ QTEVP 646_ SLVVK 651_ KEETV 656_ EDEID 661_ VRNDA 666_ VILPS 671_ CVEAE 676_ AKIHE 681_ TQETT 686_ DKSAD 691_ DAGCQ 696_ LQELR 701_ NQLLL 706_ VTEEK 711_ ENYKR 716_ QCHMF 721_ TDQIK 726_ VLQQR 731_ ILEMN 736_ DKYVK 741_ KETCH 746_ QSTET 751_ DAVFL 756_ LESIN 761_ GKSES 766_ PDHMV 771_ SQYQQ 776_ ALEEI 781_ ERLKK 786_ QCSAL 791_ QHVKA 796_ ECSQC 801_ SNNES 806_ KSEMD 811_ EMAVQ 816_ LDDVF 821_ RQLDK 826_ CSIER 831_ DQYKS 836_ EVELL 841_ EMEKS 846_ QIRSQ 851_ CEELK 856_ TEVEQ 861_ LKSTN 866_ QQTAT 871_ DVSTS 876_ SNIEE 881_ SVNHM 886_ DGESL 891_ KLRSL 896_ RVNVG 901_ QLLAM 906_ IVPDL 911_ DLQQV 916_ NYDVD 921_ VVDEI 926_ LGQVV 931_EQMSE
1: Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034)
2: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233)