Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185)
1_MPAYF 6_ QRPEN 11_ ALKRA 16_ NEFLE 21_ VGKKQ 26_ PALDV 31_ LYDVM 36_ KSKKH 41_ RTWQK 46_ IHEPI 51_ MLKYL 56_ ELCVD 61_ LRKSH 66_ LAKEG 71_ LYQYK 76_ NICQQ 81_ VNIKS 86_ LEDVV 91_ RAYLK 96_ MAEEK 101_ TEAAK 106_ EESQQ 111_ MVLDI 116_ EDLDN 121_ IQTPE 126_ SVLLS 131_ AVSGE 136_ DTQDR 141_ TDRLL 146_ LTPWV 151_ KFLWE 156_ SYRQC 161_ LDLLR 166_ NNSRV 171_ ERLYH 176_ DIAQQ 181_ AFKFC 186_ LQYTR 191_ KAEFR 196_ KLCDN 201_ LRMHL 206_ SQIQR 211_ HHNQS 216_ TAINL 221_ NNPES 226_ QSMHL 231_ ETRLV 236_ QLDSA 241_ ISMEL 246_ WQEAF 251_ KAVED 256_ IHGLF 261_ SLSKK 266_ PPKPQ 271_ LMANY 276_ YNKVS 281_ TVFWK 286_ SGNAL 291_ FHAST 296_ LHRLY 301_ HLSRE 306_ MRKNL 311_ TQDEM 316_ QRMST 321_ RVLLA 326_ TLSIP 331_ ITPER 336_ TDIAR 341_ LLDMD 346_ GIIVE 351_ KQRRL 356_ ATLLG 361_ LQAPP 366_ TRIGL 371_ INDMV 376_ RFNVL 381_ QYVVP 386_ EVKDL 391_ YNWLE 396_ VEFNP 401_ LKLCE 406_ RVTKV 411_ LNWVR 416_ EQPEK 421_ EPELQ 426_ QYVPQ 431_ LQNNT 436_ ILRLL 441_ QQVSQ 446_ IYQSI 451_ EFSRL 456_ TSLVP 461_ FVDAF 466_ QLERA 471_ IVDAA 476_ RHCDL 481_ QVRID 486_ HTSRT 491_ LSFGS 496_ DLNYA 501_ TREDA 506_ PIGPH 511_ LQSMP 516_ SEQIR 521_ NQLTA 526_ MSSVL 531_ AKALE 536_ VIKPA 541_ HILQE 546_ KEEQH 551_ QLAVT 556_ AYLKN 561_ SRKEH 566_ QRILA 571_ RRQTI 576_ EERKE 581_ RLESL 586_ NIQRE 591_ KEELE 596_ QREAE 601_ LQKVR 606_ KAEEE 611_ RLRQE 616_ AKERE 621_ KERIL 626_ QEHEQ 631_ IKKKT 636_ VRERL 641_ EQIKK 646_ TELGA 651_ KAFKD 656_ IDIED 661_ LEELD 666_ PDFIM 671_ AKQVE 676_ QLEKE 681_ KKELQ 686_ ERLKN 691_ QEKKI 696_ DYFER 701_ AKRLE 706_ EIPLI 711_ KSAYE 716_ EQRIK 721_ DMDLW 726_ EQQEE 731_ ERITT 736_ MQLER 741_ EKALE 746_ HKNRM 751_ SRMLE 756_ DRDLF 761_ VMRLK 766_ AARQS 771_ VYEEK 776_ LKQFE 781_ ERLAE 786_ ERHNR 791_ LEERK 796_ RQRKE 801_ ERRIT 806_ YYREK 811_ EEEEQ 816_ RRAEE 821_ QMLKE 826_ REERE 831_ RAERA 836_ KREEE 841_ LREYQ 846_ ERVKK 851_ LEEVE 856_ RKKRQ 861_ RELEI 866_ EERER 871_ RREEE 876_ RRLGD 881_ SSLSR 886_ KDSRW 891_ GDRDS 896_ EGTWR 901_ KGPEA 906_ DSEWR 911_ RGPPE 916_ KEWRR 921_ GEGRD 926_ EDRSH 931_ RRDEE 936_ RPRRL 941_ GDDED 946_ REPSL 951_ RPDDD 956_ RVPRR 961_ GMDDD 966_ RGPRR 971_ GPEED 976_ RFSRR 981_ GADDD 986_ RPSWR 991_ NTDDD 996_ RPPRR 1001_ IADED 1006_ RGNWR 1011_ HADDD 1016_ RPPRR 1021_ GLDED 1026_ RGSWR 1031_ TADED 1036_ RGPRR 1041_ GMDDD 1046_ RGPRR 1051_ GGADD 1056_ ERSSW 1061_ RNADD 1066_ DRGPR 1071_ RGLDD 1076_ DRGPR 1081_ RGMDD 1086_ DRGPR 1091_ RGMDD 1096_ DRGPR 1101_ RGMDD 1106_ DRGPR 1111_ RGLDD 1116_ DRGPW 1121_ RNADD 1126_ DRIPR 1131_ RGAED 1136_ DRGPW 1141_ RNMDD 1146_ DRLSR 1151_ RADDD 1156_ RFPRR 1161_ GDDSR 1166_ PGPWR 1171_ PLVKP 1176_ GGWRE 1181_ KEKAR 1186_ EESWG 1191_ PPRES 1196_ RPSEE 1201_ REWDR 1206_ EKERD 1211_ RDNQD 1216_ REEND 1221_ KDPER 1226_ ERDRE 1231_ RDVDR 1236_ EDRFR 1241_ RPRDE 1246_ GGWRR 1251_ GPAEE 1256_ SSSWR 1261_ DSSRR 1266_ DDRDR 1271_ DDRRR 1276_ ERDDR 1281_ RDLRE 1286_ RRDLR 1291_ DDRDR 1296_ RGPPL 1301_ RSERE 1306_ EVSSW 1311_ RRADD 1316_ RKDDR 1321_ VEERD 1326_ PPRRV 1331_ PPPAL 1336_ SRDRE 1341_ RDRDR 1346_ EREGE 1351_ KEKAS 1356_ WRAEK 1361_ DRESL 1366_ RRTKN 1371_ ETDED 1376_GWTTV
1: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815)
2: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634)
3: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426)