Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)
1_MNSAE 6_ QTVTW 11_ LITLG 16_ VLESP 21_ KKTIS 26_ DPEGF 31_ LQASL 36_ KDGVV 41_ LCRLL 46_ ERLLP 51_ GTIEK 56_ VYPEP 61_ RSESE 66_ CLSNI 71_ REFLR 76_ GCGAS 81_ LRLEL 86_ LFPPS 91_ QPPQH 96_ LVTTI 101_ LLSAS 106_ TFDAN 111_ DLYQG 116_ QNFNK 121_ VLSSL 126_ VTLNK 131_ VTADI 136_ GLGSD 141_ SVCAR 146_ PSSHR 151_ IKSFD 156_ SLGSQ 161_ SLHTR 166_ TSKLF 171_ QGQYR 176_ SLDMT 181_ DNSNN 186_ QLVVR 191_ AKFNF 196_ QQTNE 201_ DELSF 206_ SKGDV 211_ IHVTR 216_ VEEGG 221_ WWEGT 226_ LNGRT 231_ GWFPS 236_ NYVRE 241_ VKASE 246_ KPVSP 251_ KSGTL 256_ KSPPK 261_ GFDTT 266_ AINKS 271_ YYNVV 276_ LQNIL 281_ ETENE 286_ YSKEL 291_ QTVLS 296_ TYLRP 301_ LQTSE 306_ KLSSA 311_ NISYL 316_ MGNLE 321_ EICSF 326_ QQMLV 331_ QSLEE 336_ CTKLP 341_ EAQQR 346_ VGGCF 351_ LNLMP 356_ QMKTL 361_ YLTYC 366_ ANHPS 371_ AVNVL 376_ TEHSE 381_ ELGEF 386_ METKG 391_ ASSPG 396_ ILVLT 401_ TGLSK 406_ PFMRL 411_ DKYPT 416_ LLKEL 421_ ERHME 426_ DYHTD 431_ RQDIQ 436_ KSMAA 441_ FKNLS 446_ AQCQE 451_ VRKRK 456_ ELELQ 461_ ILTEA 466_ IRNWE 471_ GDDIK 476_ TLGNV 481_ TYMSQ 486_ VLIQC 491_ AGSEE 496_ KNERY 501_ LLLFP 506_ NVLLM 511_ LSASP 516_ RMSGF 521_ IYQGK 526_ LPTTG 531_ MTITK 536_ LEDSE 541_ NHRNA 546_ FEISG 551_ SMIER 556_ ILVSC 561_ NNQQD 566_ LQEWV 571_ EHLQK 576_ QTKVT 581_ SVGNP 586_ TIKPH 591_ SVPSH 596_ TLPSH 601_ PVTPS 606_ SKHAD 611_ SKPAP 616_ LTPAY 621_ HTLPH 626_ PSHHG 631_ TPHTT 636_ INWGP 641_ LEPPK 646_ TPKPW 651_ SLSCL 656_ RPAPP 661_ LRPSA 666_ ALCYK 671_ EDLSK 676_ SPKTM 681_ KKLLP 686_ KRKPE 691_ RKPSD 696_ EEFAS 701_ RKSTA 706_ ALEED 711_ AQILK 716_ VIEAY 721_ CTSAK 726_ TRQTL 731_ NSTWQ 736_ GTDLM 741_ HNHVL 746_ ADDDQ 751_ PSLDS 756_ LGRRS 761_ SLSRL 766_ EPSDL 771_ SEDSD 776_ YDSIW 781_ TAHSY 786_ RMGST 791_ SRKSC 796_CSYIS
1: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons