Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
1_MLKCI 6_ PLWRC 11_ NRHVE 16_ SVDKR 21_ HCSLQ 26_ AVPEE 31_ IYRYS 36_ RSLEE 41_ LLLDA 46_ NQLRE 51_ LPKPF 56_ FRLLN 61_ LRKLG 66_ LSDNE 71_ IQRLP 76_ PEVAN 81_ FMQLV 86_ ELDVS 91_ RNDIP 96_ EIPES 101_ IKFCK 106_ ALEIA 111_ DFSGN 116_ PLSRL 121_ PDGFT 126_ QLRSL 131_ AHLAL 136_ NDVSL 141_ QALPG 146_ DVGNL 151_ ANLVT 156_ LELRE 161_ NLLKS 166_ LPASL 171_ SFLVK 176_ LEQLD 181_ LGGND 186_ LEVLP 191_ DTLGA 196_ LPNLR 201_ ELWLD 206_ RNQLS 211_ ALPPE 216_ LGNLR 221_ RLVCL 226_ DVSEN 231_ RLEEL 236_ PAELG 241_ GLVLL 246_ TDLLL 251_ SQNLL 256_ RRLPD 261_ GIGQL 266_ KQLSI 271_ LKVDQ 276_ NRLCE 281_ VTEAI 286_ GDCEN 291_ LSELI 296_ LTENL 301_ LMALP 306_ RSLGK 311_ LTKLT 316_ NLNVD 321_ RNHLE 326_ ALPPE 331_ IGGCV 336_ ALSVL 341_ SLRDN 346_ RLAVL 351_ PPELA 356_ HTTEL 361_ HVLDV 366_ AGNRL 371_ QSLPF 376_ ALTHL 381_ NLKAL 386_ WLAEN 391_ QAQPM 396_ LRFQT 401_ EDDAR 406_ TGEKV 411_ LTCYL 416_ LPQQP 421_ PPSLE 426_ DAGQQ 431_ GSLSE 436_ TWSDA 441_ PPSRV 446_ SVIQF 451_ LEAPI 456_ GDEDA 461_ EEAAA 466_ EKRGL 471_ QRRAT 476_ PHPSE 481_ LKVMK 486_ RSIEG 491_ RRSEA 496_ CPCQP 501_ DSGSP 506_ LPAEE 511_ EKRLS 516_ AESGL 521_ SEDSR 526_ PSAST 531_ VSEAE 536_ PEGPS 541_ AEAQG 546_ GSQQE 551_ ATTAG 556_ GEEDA 561_ EEDYQ 566_ EPTVH 571_ FAEDA 576_ LLPGD 581_ DREIE 586_ EGQPE 591_ APWTL 596_ PGGRQ 601_ RLIRK 606_ DTPHY 611_ KKHFK 616_ ISKLP 621_ QPEAV 626_ VALLQ 631_ GMQPD 636_ GEGPV 641_ APGGW 646_ HNGPH 651_ APWAP 656_ RAQKE 661_ EEEEE 666_ EGSPQ 671_ EEEEE 676_ EEEEN 681_ RAEEE 686_ EASTE 691_ EEDKE 696_ GAVVS 701_ APSVK 706_ GVSFD 711_ QANNL 716_ LIEPA 721_ RIEEE 726_ ELTLT 731_ ILRQT 736_ GGLGI 741_ SIAGG 746_ KGSTP 751_ YKGDD 756_ EGIFI 761_ SRVSE 766_ EGPAA 771_ RAGVR 776_ VGDKL 781_ LEVNG 786_ VALQG 791_ AEHHE 796_ AVEAL 801_ RGAGT 806_ AVQMR 811_ VWRER 816_ MVEPE 821_ NAVTI 826_ TPLRP 831_ EDDYS 836_ PRERR 841_ GGGLR 846_ LPLLP 851_ PESPG 856_ PLRQR 861_ HVACL 866_ ARSER 871_ GLGFS 876_ IAGGK 881_ GSTPY 886_ RAGDA 891_ GIFVS 896_ RIAEG 901_ GAAHR 906_ AGTLQ 911_ VGDRV 916_ LSING 921_ VDVTE 926_ ARHDH 931_ AVSLL 936_ TAASP 941_ TIALL 946_ LEREA 951_ GGPLP 956_ PSPLP 961_ HSSPP 966_ TAAVA 971_ TTSIT 976_ TATPG 981_ VPGLP 986_ SLAPS 991_ LLAAA 996_ LEGPY 1001_ PVEEI 1006_ RLPRA 1011_ GGPLG 1016_ LSIVG 1021_ GSDHS 1026_ SHPFG 1031_ VQEPG 1036_ VFISK 1041_ VLPRG 1046_ LAARS 1051_ GLRVG 1056_ DRILA 1061_ VNGQD 1066_ VRDAT 1071_ HQEAV 1076_ SALLR 1081_ PCLEL 1086_ SLLVR 1091_ RDPAP 1096_ PGLRE 1101_ LCIQK 1106_ APGER 1111_ LGISI 1116_ RGGAR 1121_ GHAGN 1126_ PRDPT 1131_ DEGIF 1136_ ISKVS 1141_ PTGAA 1146_ GRDGR 1151_ LRVGL 1156_ RLLEV 1161_ NQQSL 1166_ LGLTH 1171_ GEAVQ 1176_ LLRSV 1181_ GDTLT 1186_ VLVCD 1191_ GFEAS 1196_ TDAAL 1201_ EVSPG 1206_ VIANP 1211_ FAAGI 1216_ GHRNS 1221_ LESIS 1226_ SIDRE 1231_ LSPEG 1236_ PGKEK 1241_ ELPGQ 1246_ TLHWG 1251_ PEATE 1256_ AAGRG 1261_ LQPLK 1266_ LDYRA 1271_ LAAVP 1276_ SAGSV 1281_ QRVPS 1286_ GAAGG 1291_ KMAES 1296_ PCSPS 1301_ GQQPP 1306_ SPPSP 1311_ DELPA 1316_ NVKQA 1321_ YRAFA 1326_ AVPTS 1331_ HPPED 1336_ APAQP 1341_ PTPGP 1346_ AASPE 1351_ QLSFR 1356_ ERQKY 1361_ FELEV 1366_ RVPQA 1371_ EGPPK 1376_ RVSLV 1381_ GADDL 1386_ RKMQE 1391_ EEARK 1396_ LQQKR 1401_ AQMLR 1406_ EAAEA 1411_ GAEAR 1416_ LALDG 1421_ ETLGE 1426_ EEQED 1431_ EQPPW 1436_ ASPSP 1441_ TSRQS 1446_ PASPP 1451_ PLGGG 1456_ APVRT 1461_ AKAER 1466_ RHQER 1471_ LRVQS 1476_ PEPPA 1481_ PERAL 1486_ SPAEL 1491_ RALEA 1496_ EKRAL 1501_ WRAAR 1506_ MKSLE 1511_ QDALR 1516_ AQMVL 1521_ SRSQE 1526_ GRGTR 1531_ GPLER 1536_ LAEAP 1541_ SPAPT 1546_ PSPTP 1551_ VEDLG 1556_ PQTST 1561_ SPGRL 1566_ SPDFA 1571_ EELRS 1576_ LEPSP 1581_ SPGPQ 1586_ EEDGE 1591_ VALVL 1596_ LGRPS 1601_ PGAVG 1606_ PEDVA 1611_ LCSSR 1616_ RPVRP 1621_GRRGL
1: Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672)