Tubulin--tyrosine ligase-like protein 12 (Inactive tubulin--tyrosine ligase-like protein 12)
1_MEAER 6_ GPERR 11_ PAERS 16_ SPGQT 21_ PEEGA 26_ QALAE 31_ FAALH 36_ GPALR 41_ ASGVP 46_ ERYWG 51_ RLLHK 56_ LEHEV 61_ FDAGE 66_ VFGIM 71_ QVEEV 76_ EEEED 81_ EAARE 86_ VRKQQ 91_ PNPGN 96_ ELCYK 101_ VIVTR 106_ ESGLQ 111_ AAHPN 116_ SIFLI 121_ DHAWT 126_ CRVEH 131_ ARQQL 136_ QQVPG 141_ LLHRM 146_ ANLMG 151_ IEFHG 156_ ELPST 161_ EAVAL 166_ VLEEM 171_ WKFNQ 176_ TYQLA 181_ HGTAE 186_ EKMPV 191_ WYIMD 196_ EFGSR 201_ IQHAD 206_ VPSFA 211_ TAPFF 216_ YMPQQ 221_ VAYTL 226_ LWPLR 231_ DLDTG 236_ EEVTR 241_ DFAYG 246_ ETDPL 251_ IRKCM 256_ LLPWA 261_ PTDML 266_ DLSSC 271_ TPEPP 276_ AEHYQ 281_ AILEE 286_ NKEKL 291_ PLDIN 296_ PVVHP 301_ HGHIF 306_ KVYTD 311_ VQQVA 316_ SSLTH 321_ PRFTL 326_ TQSEA 331_ DADIL 336_ FNFSH 341_ FKDYR 346_ KLSQE 351_ RPGVL 356_ LNQFP 361_ CENLL 366_ TVKDC 371_ LASIA 376_ RRAGG 381_ PEGPP 386_ WLPRT 391_ FNLRT 396_ ELPQF 401_ VSYFQ 406_ QRERW 411_ GEDNH 416_ WICKP 421_ WNLAR 426_ SLDTH 431_ VTKSL 436_ HSIIR 441_ HREST 446_ PKVVS 451_ KYIES 456_ PVLFL 461_ REDVG 466_ KVKFD 471_ IRYIV 476_ LLRSV 481_ RPLRL 486_ FVYDV 491_ FWLRF 496_ SNRAF 501_ ALNDL 506_ DDYEK 511_ HFTVM 516_ NYDPD 521_ VVLKQ 526_ VHCEE 531_ FIPEF 536_ EKQYP 541_ EFPWT 546_ DVQAE 551_ IFRAF 556_ TELFQ 561_ VACAK 566_ PPPLG 571_ LCDYP 576_ SSRAM 581_ YAVDL 586_ MLKWD 591_ NGPDG 596_ RRVMQ 601_ PQILE 606_ VNFNP 611_ DCERA 616_ CRYHP 621_ TFFND 626_ VFSTL 631_ FLDQP 636_GGCHV
1: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935)