DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit)
1_MSASA 6_ QQLAE 11_ ELQIF 16_ GLDCE 21_ EALIE 26_ KLVEL 31_ CVQYG 36_ QNEEG 41_ MVGEL 46_ IAFCT 51_ STHKV 56_ GLTSE 61_ ILNSF 66_ EHEFL 71_ SKRLS 76_ KARHS 81_ TCKDS 86_ GHAGA 91_ RDIVS 96_ IQELI 101_ EVEEE 106_ EEILL 111_ NSYTT 116_ PSKGS 121_ QKRAI 126_ STPET 131_ PLTKR 136_ SVSTR 141_ SPHQL 146_ LSPSS 151_ FSPSA 156_ TPSQK 161_ YNSRS 166_ NRGEV 171_ VTSFG 176_ LAQGV 181_ SWSGR 186_ GGAGN 191_ ISLKV 196_ LGCPE 201_ ALTGS 206_ YKSMF 211_ QKLPD 216_ IREVL 221_ TCKIE 226_ ELGSE 231_ LKEHY 236_ KIEAF 241_ TPLLA 246_ PAQEP 251_ VTLLG 256_ QIGCD 261_ SNGKL 266_ NNKSV 271_ ILEGD 276_ REHSS 281_ GAQIP 286_ VDLSE 291_ LKEYS 296_ LFPGQ 301_ VVIME 306_ GINTT 311_ GRKLV 316_ ATKLY 321_ EGVPL 326_ PFYQP 331_ TEEDA 336_ DFEQS 341_ MVLVA 346_ CGPYT 351_ TSDSI 356_ TYDPL 361_ LDLIA 366_ VINHD 371_ RPDVC 376_ ILFGP 381_ FLDAK 386_ HEQVE 391_ NCLLT 396_ SPFED 401_ IFKQC 406_ LRTII 411_ EGTRS 416_ SGSHL 421_ VFVPS 426_ LRDVH 431_ HEPVY 436_ PQPPF 441_ SYSDL 446_ SREDK 451_ KQVQF 456_ VSEPC 461_ SLSIN 466_ GVIFG 471_ LTSTD 476_ LLFHL 481_ GAEEI 486_ SSSSG 491_ TSDRF 496_ SRILK 501_ HILTQ 506_ RSYYP 511_ LYPPQ 516_ EDMAI 521_ DYESF 526_ YVYAQ 531_ LPVTP 536_ DVLII 541_ PSELR 546_ YFVKD 551_ VLGCV 556_ CVNPG 561_ RLTKG 566_ QVGGT 571_ FARLY 576_ LRRPA 581_ ADGAE 586_ RQSPC 591_IAVQV
1: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity)