Double C2-like domain-containing protein alpha (Doc2) (Doc2-alpha)
1_MRGRR 6_ GDRMT 11_ INIQE 16_ HMAIN 21_ VCPGP 26_ IRPIR 31_ QISDY 36_ FPRGP 41_ GPEGG 46_ GGGGG 51_ EAPAH 56_ LVPLA 61_ LAPPA 66_ ALLGA 71_ TTPED 76_ GAEVD 81_ SYDSD 86_ DATAL 91_ GTLEF 96_ DLLYD 101_ RASCT 106_ LHCSI 111_ LRAKG 116_ LKPMD 121_ FNGLA 126_ DPYVK 131_ LHLLP 136_ GACKA 141_ NKLKT 146_ KTQRN 151_ TLNPV 156_ WNEDL 161_ TYSGI 166_ TDDDI 171_ THKVL 176_ RIAVC 181_ DEDKL 186_ SHNEF 191_ IGEIR 196_ VPLRR 201_ LKPSQ 206_ KKHFN 211_ ICLER 216_ QVPLA 221_ SPSSM 226_ SAALR 231_ GISCY 236_ LKELE 241_ QAEQG 246_ QGLLE 251_ ERGRI 256_ LLSLS 261_ YSSRR 266_ RGLLV 271_ GILRC 276_ AHLAA 281_ MDVNG 286_ YSDPY 291_ VKTYL 296_ RPDVD 301_ KKSKH 306_ KTCVK 311_ KKTLN 316_ PEFNE 321_ EFFYE 326_ IELST 331_ LATKT 336_ LEVTV 341_ WDYDI 346_ GKSND 351_ FIGGV 356_ SLGPG 361_ ARGEA 366_ RKHWS 371_ DCLQQ 376_ PDAAL 381_ ERWHT 386_ LTSEL 391_PPAAG
1: Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells