Double C2-like domain-containing protein beta (Doc2-beta)
1_MTLRR 6_ RGEKA 11_ TISIQ 16_ EHMAI 21_ DVCPG 26_ PIRPI 31_ KQISD 36_ YFPRF 41_ PRGLP 46_ PDAGP 51_ RAAAP 56_ PDAPA 61_ RPAVA 66_ GAGRR 71_ SPSDG 76_ AREDD 81_ EDVDQ 86_ LFGAY 91_ GSSPG 96_ PSPGP 101_ SPARP 106_ PAKPP 111_ EDEPD 116_ ADGYE 121_ SDDCT 126_ ALGTL 131_ DFSLL 136_ YDQEN 141_ NALHC 146_ TITKA 151_ KGLKP 156_ MDHNG 161_ LADPY 166_ VKLHL 171_ LPGAS 176_ KANKL 181_ RTKTL 186_ RNTLN 191_ PTWNE 196_ TLTYY 201_ GITDE 206_ DMIRK 211_ TLRIS 216_ VCDED 221_ KFRHN 226_ EFIGE 231_ TRVPL 236_ KKLKP 241_ NHTKT 246_ FSICL 251_ EKQLP 256_ VDKTE 261_ DKSLE 266_ ERGRI 271_ LISLK 276_ YSSQK 281_ QGLLV 286_ GIVRC 291_ AHLAA 296_ MDANG 301_ YSDPY 306_ VKTYL 311_ RPDVD 316_ KKSKH 321_ KTAVK 326_ KKTLN 331_ PEFNE 336_ EFCYE 341_ IKHGD 346_ LAKKS 351_ LEVTV 356_ WDYDI 361_ GKSND 366_ FIGGV 371_ VLGIH 376_ AKGER 381_ LKHWF 386_ DCLKN 391_ KDKRI 396_ ERWHT 401_ LTSEL 406_PGAVL
1: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity)