Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
1_MTRWV 6_ PTKRE 11_ EKYGV 16_ AFYNY 21_ DARGA 26_ DELSL 31_ QIGDT 36_ VHILE 41_ TYEGW 46_ YRGYT 51_ LRKKS 56_ KKGIF 61_ PASYI 66_ HLKEA 71_ IVEGK 76_ GQHET 81_ VIPGD 86_ LPLIQ 91_ EVTTT 96_ LREWS 101_ TIWRQ 106_ LYVQD 111_ NREMF 116_ RSVRH 121_ MIYDL 126_ IEWRS 131_ QILSG 136_ TLPQD 141_ ELKEL 146_ KKKVT 151_ AKIDY 156_ GNRIL 161_ DLDLV 166_ VRDED 171_ GNILD 176_ PELTS 181_ TISLF 186_ RAHEI 191_ ASKQV 196_ EERLQ 201_ EEKSQ 206_ KQNID 211_ INRQA 216_ KFAAT 221_ PSLAL 226_ FVNLK 231_ NVVCK 236_ IGEDA 241_ EVLMS 246_ LYDPV 251_ ESKFI 256_ SENYL 261_ VRWSS 266_ SGLPK 271_ DIDRL 276_ HNLRA 281_ VFTDL 286_ GSKDL 291_ KREKI 296_ SFVCQ 301_ IVRVG 306_ RMELR 311_ DNNTR 316_ KLTSG 321_ LRRPF 326_ GVAVM 331_ DVTDI 336_ INGKV 341_ DDEDK 346_ QHFIP 351_ FQPVA 356_ GENDF 361_ LQTVI 366_ NKVIA 371_ AKEVN 376_ HKGQG 381_ LWVTL 386_ KLLPG 391_ DIHQI 396_ RKEFP 401_ HLVDR 406_ TTAVA 411_ RKTGF 416_ PEIIM 421_ PGDVR 426_ NDIYV 431_ TLVQG 436_ DFDKG 441_ SKTTA 446_ KNVEV 451_ TVSVY 456_ DEDGK 461_ RLEHV 466_ IFPGA 471_ GDEAI 476_ SEYKS 481_ VIYYQ 486_ VKQPR 491_ WFETV 496_ KVAIP 501_ IEDVN 506_ RSHLR 511_ FTFRH 516_ RSSQD 521_ SKDKS 526_ EKIFA 531_ LAFVK 536_ LMRYD 541_ GTTLR 546_ DGEHD 551_ LIVYK 556_ AEAKK 561_ LEDAA 566_ TYLSL 571_ PSTKA 576_ ELEEK 581_ GHSAT 586_ GKSMQ 591_ SLGSC 596_ TISKD 601_ SFQIS 606_ TLVCS 611_ TKLTQ 616_ NVDLL 621_ GLLKW 626_ RSNTS 631_ LLQQN 636_ LRQLM 641_ KVDGG 646_ EVVKF 651_ LQDTL 656_ DALFN 661_ IMMEN 666_ SESET 671_ FDTLV 676_ FDALV 681_ FIIGL 686_ IADRK 691_ FQHFN 696_ PVLET 701_ YIKKH 706_ FSATL 711_ AYTKL 716_ TKVLK 721_ NYVDG 726_ AEKPG 731_ VNEQL 736_ YKAMK 741_ ALESI 746_ FKFIV 751_ RSRIL 756_ FNQLY 761_ ENKGE 766_ ADFVE 771_ SLLQL 776_ FRSIN 781_ DMMSS 786_ MSDQT 791_ VRVKG 796_ AALKY 801_ LPTIV 806_ NDVKL 811_ VFDPK 816_ ELSKM 821_ FTEFI 826_ LNVPM 831_ GLLTI 836_ QKLYC 841_ LIEIV 846_ HSDLF 851_ TQHDC 856_ REILL 861_ PMMTD 866_ QLKYH 871_ LERQE 876_ DLEAC 881_ CQLLS 886_ HILEV 891_ LYRKD 896_ VGPTQ 901_ RHVQI 906_ IMEKL 911_ LRTVN 916_ RTVIS 921_ MGRDS 926_ ELIGN 931_ FVACM 936_ TAILR 941_ QMEDY 946_ HYAHL 951_ IKTFG 956_ KMRTD 961_ VVDFL 966_ METFI 971_ MFKNL 976_ IGKNV 981_ YPFDW 986_ VIMNM 991_ VQNKV 996_ FLRAI 1001_ NQYAD 1006_ MLNKK 1011_ FLDQA 1016_ NFELQ 1021_ LWNNY 1026_ FHLAV 1031_ AFLTQ 1036_ ESLQL 1041_ ENFSS 1046_ AKRAK 1051_ ILNKY 1056_ GDMRR 1061_ QIGFE 1066_ IRDMW 1071_ YNLGQ 1076_ HKIKF 1081_ IPEMV 1086_ GPILE 1091_ MTLIP 1096_ ETELR 1101_ KATIP 1106_ IFFDM 1111_ MQCEF 1116_ HSTRS 1121_ FQMFE 1126_ NEIIT 1131_ KLDHE 1136_ VEGGR 1141_ GDEQY 1146_ KVLFD 1151_ KILLE 1156_ HCRKH 1161_ KYLAK 1166_ TGETF 1171_ VKLVV 1176_ RLMER 1181_ LLDYR 1186_ TIMHD 1191_ ENKEN 1196_ RMSCT 1201_ VNVLN 1206_ FYKEI 1211_ EREEM 1216_ YIRYL 1221_ YKLCD 1226_ LHKEC 1231_ DNYTE 1236_ AAYTL 1241_ LLHAK 1246_ LLKWS 1251_ EDVCV 1256_ AHLTQ 1261_ RDGYQ 1266_ ATTQG 1271_ QLKEQ 1276_ LYQEI 1281_ IHYFD 1286_ KGKMW 1291_ EEAIA 1296_ LGKEL 1301_ AEQYE 1306_ NEMFD 1311_ YEQLS 1316_ ELLKK 1321_ QAQFY 1326_ ENIVK 1331_ VIRPK 1336_ PDYFA 1341_ VGYYG 1346_ QGFPT 1351_ FLRGK 1356_ VFIYR 1361_ GKEYE 1366_ RREDF 1371_ EARLL 1376_ TQFPN 1381_ AEKMK 1386_ TTSPP 1391_ GDDIK 1396_ NSPGQ 1401_ YIQCF 1406_ TVKPK 1411_ LDLPP 1416_ KFHRP 1421_ VSEQI 1426_ VSFYR 1431_ VNEVQ 1436_ RFEYS 1441_ RPIRK 1446_ GEKNP 1451_ DNEFA 1456_ NMWIE 1461_ RTIYT 1466_ TAYKL 1471_ PGILR 1476_ WFEVK 1481_ SVFMV 1486_ EISPL 1491_ ENAIE 1496_ TMQLT 1501_ NDKIN 1506_ SMVQQ 1511_ HLDDP 1516_ SLPIN 1521_ PLSML 1526_ LNGIV 1531_ DPAVM 1536_ GGFAN 1541_ YEKAF 1546_ FTDRY 1551_ LQEHP 1556_ EAHEK 1561_ IEKLK 1566_ DLIAW 1571_ QIPFL 1576_ AEGIR 1581_ IHGDK 1586_ VTEAL 1591_ RPFHE 1596_ RMEAC 1601_ FKQLK 1606_ EKVEK 1611_ EYGVR 1616_ IMPSS 1621_ LDDRR 1626_ GSRPR 1631_ SMVRS 1636_ FTMPS 1641_ SSRPL 1646_ SVASV 1651_ SSLSS 1656_ DSTPS 1661_ RPGSD 1666_ GFALE 1671_ PLLPK 1676_ KMHSR 1681_ SQDKL 1686_ DKDDL 1691_ EKEKK 1696_ DKKKE 1701_ KRNSK 1706_ HQEIF 1711_ EKEFK 1716_ PTDIS 1721_ LQQSE 1726_ AVILS 1731_ ETISP 1736_ LRPQR 1741_ PKSQV 1746_ MNVIG 1751_ SERRF 1756_ SVSPS 1761_ SPSSQ 1766_ QTPPP 1771_ VTPRA 1776_ KLSFS 1781_ MQSSL 1786_ ELNGM 1791_ TGADV 1796_ ADVPP 1801_ PLPLK 1806_ GSVAD 1811_ YGNLM 1816_ ENQDL 1821_ LGSPT 1826_ PPPPP 1831_ PHQRH 1836_ LPPPL 1841_ PSKTP 1846_ PPPPP 1851_ KTTRK 1856_QASVD
1: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152)