Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1)
1_MAKDA 6_ GLIEA 11_ NGELK 16_ VFIDQ 21_ NLSPG 26_ KGVVS 31_ LVAVH 36_ PSTVN 41_ PLGKQ 46_ LLPKT 51_ FGQSN 56_ VNIAQ 61_ QVVIG 66_ TPQRP 71_ AASNT 76_ LVVGS 81_ PHTPS 86_ THFAS 91_ QNQPS 96_ DSSPW 101_ SAGKR 106_ NRKGE 111_ KNGKG 116_ LRHFS 121_ MKVCE 126_ KVQRK 131_ GTTSY 136_ NEVAD 141_ ELVAE 146_ FSAAD 151_ NHILP 156_ NESAY 161_ DQKNI 166_ RRRVY 171_ DALNV 176_ LMAMN 181_ IISKE 186_ KKEIK 191_ WIGLP 196_ TNSAQ 201_ ECQNL 206_ EVERQ 211_ RRLER 216_ IKQKQ 221_ SQLQE 226_ LILQQ 231_ IAFKN 236_ LVQRN 241_ RHAEQ 246_ QASRP 251_ PPPNS 256_ VIHLP 261_ FIIVN 266_ TSKKT 271_ VIDCS 276_ ISNDK 281_ FEYLF 286_ NFDNT 291_ FEIHD 296_ DIEVL 301_ KRMGM 306_ ACGLE 311_ SGSCS 316_ AEDLK 321_ MARSL 326_ VPKAL 331_ EPYVT 336_ EMAQG 341_ TVGGV 346_ FITTA 351_ GSTSN 356_ GTRFS 361_ ASDLT 366_ NGADG 371_ MLATS 376_ SNGSQ 381_ YSGSR 386_ VETPV 391_ SYVGE 396_ DDEED 401_DDFNE
1: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:7739537, PubMed:8405995). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812)