Peptidyl-tRNA hydrolase ICT1, mitochondrial (EC 3.1.1.29) (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Digestion substraction 1) (DS-1) (Immature colon carcinoma transcript 1 protein) (Mitochondrial large ribosomal subunit protein mL62)
1_MAATR 6_ CLRWG 11_ LSRAG 16_ VWLLP 21_ PPARC 26_ PRRAL 31_ HKQKD 36_ GTEFK 41_ SIYSL 46_ DKLYP 51_ ESQGS 56_ DTAWR 61_ VPNGA 66_ KQADS 71_ DIPLD 76_ RLTIS 81_ YCRSS 86_ GPGGQ 91_ NVNKV 96_ NSKAE 101_ VRFHL 106_ ATAEW 111_ IAEPV 116_ RQKIA 121_ ITHKN 126_ KINRL 131_ GELIL 136_ TSESS 141_ RYQFR 146_ NLADC 151_ LQKIR 156_ DMITE 161_ ASQTP 166_ KEPTK 171_ EDVKL 176_ HRIRI 181_ ENMNR 186_ ERLRQ 191_ KRIHS 196_ AVKTS 201_RRVDM
1: Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit (PubMed:20186120, PubMed:33878294). Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation (PubMed:33878294). Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (PubMed:20186120, PubMed:33878294)