Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)
1_MAQSK 6_ RHVYS 11_ RTPSG 16_ SRMSA 21_ EASAR 26_ PLRVG 31_ SRVEV 36_ IGKGH 41_ RGTVA 46_ YVGAT 51_ LFATG 56_ KWVGV 61_ ILDEA 66_ KGKND 71_ GTVQG 76_ RKYFT 81_ CDEGH 86_ GIFVR 91_ QSQIQ 96_ VFEDG 101_ ADTTS 106_ PETPD 111_ SSASK 116_ VLKRE 121_ GTDTT 126_ AKTSK 131_ LRGLK 136_ PKKAP 141_ TARKT 146_ TTRRP 151_ KPTRP 156_ ASTGV 161_ AGASS 166_ SLGPS 171_ GSASA 176_ GELSS 181_ SEPST 186_ PAQTP 191_ LAAPI 196_ IPTPV 201_ LTSPG 206_ AVPPL 211_ PSPSK 216_ EEEGL 221_ RAQVR 226_ DLEEK 231_ LETLR 236_ LKRAE 241_ DKAKL 246_ KELEK 251_ HKIQL 256_ EQVQE 261_ WKSKM 266_ QEQQA 271_ DLQRR 276_ LKEAR 281_ KEAKE 286_ ALEAK 291_ ERYME 296_ EMADT 301_ ADAIE 306_ MATLD 311_ KEMAE 316_ ERAES 321_ LQQEV 326_ EALKE 331_ RVDEL 336_ TTDLE 341_ ILKAE 346_ IEEKG 351_ SDGAA 356_ SSYQL 361_ KQLEE 366_ QNARL 371_ KDALV 376_ RMRDL 381_ SSSEK 386_ QEHVK 391_ LQKLM 396_ EKKNQ 401_ ELEVV 406_ RQQRE 411_ RLQEE 416_ LSQAE 421_ STIDE 426_ LKEQV 431_ DAALG 436_ AEEMV 441_ EMLTD 446_ RNLNL 451_ EEKVR 456_ ELRET 461_ VGDLE 466_ AMNEM 471_ NDELQ 476_ ENARE 481_ TELEL 486_ REQLD 491_ MAGAR 496_ VREAQ 501_ KRVEA 506_ AQETV 511_ ADYQQ 516_ TIKKY 521_ RQLTA 526_ HLQDV 531_ NRELT 536_ NQQEA 541_ SVERQ 546_ QQPPP 551_ ETFDF 556_ KIKFA 561_ ETKAH 566_ AKAIE 571_ MELRQ 576_ MEVAQ 581_ ANRHM 586_ SLLTA 591_ FMPDS 596_ FLRPG 601_ GDHDC 606_ VLVLL 611_ LMPRL 616_ ICKAE 621_ LIRKQ 626_ AQEKF 631_ ELSEN 636_ CSERP 641_ GLRGA 646_ AGEQL 651_ SFAAG 656_ LVYSL 661_ SLLQA 666_ TLHRY 671_ EHALS 676_ QCSVD 681_ VYKKV 686_ GSLYP 691_ EMSAH 696_ ERSLD 701_ FLIEL 706_ LHKDQ 711_ LDETV 716_ NVEPL 721_ TKAIK 726_ YYQHL 731_ YSIHL 736_ AEQPE 741_ DCTMQ 746_ LADHI 751_ KFTQS 756_ ALDCM 761_ SVEVG 766_ RLRAF 771_ LQGGQ 776_ EATDI 781_ ALLLR 786_ DLETS 791_ CSDIR 796_ QFCKK 801_ IRRRM 806_ PGTDA 811_ PGIPA 816_ ALAFG 821_ PQVSD 826_ TLLDC 831_ RKHLT 836_ WVVAV 841_ LQEVA 846_ AAAAQ 851_ LIAPL 856_ AENEG 861_ LLVAA 866_ LEELA 871_ FKASE 876_ QIYGT 881_ PSSSP 886_ YECLR 891_ QSCNI 896_ LISTM 901_ NKLAT 906_ AMQEG 911_ EYDAE 916_ RPPSK 921_ PPPVE 926_ LRAAA 931_ LRAEI 936_ TDAEG 941_ LGLKL 946_ EDRET 951_ VIKEL 956_ KKSLK 961_ IKGEE 966_ LSEAN 971_ VRLSL 976_ LEKKL 981_ DSAAK 986_ DADER 991_ IEKVQ 996_ TRLEE 1001_ TQALL 1006_ RKKEK 1011_ EFEET 1016_ MDALQ 1021_ ADIDQ 1026_ LEAEK 1031_ AELKQ 1036_ RLNSQ 1041_ SKRTI 1046_ EGLRG 1051_ PPPSG 1056_ IATLV 1061_ SGIAG 1066_ EEQQR 1071_ GAIPG 1076_ QAPGS 1081_ VPGPG 1086_ LVKDS 1091_ PLLLQ 1096_ QISAM 1101_ RLHIS 1106_ QLQHE 1111_ NSILK 1116_ GAQMK 1121_ ASLAS 1126_ LPPLH 1131_ VAKLS 1136_ HEGPG 1141_ SELPA 1146_ GALYR 1151_ KTSQL 1156_ LETLN 1161_ QLSTH 1166_ THVVD 1171_ ITRTS 1176_ PAAKS 1181_ PSAQL 1186_ MEQVA 1191_ QLKSL 1196_ SDTVE 1201_ KLKDE 1206_ VLKET 1211_ VSQRP 1216_ GATVP 1221_ TDFAT 1226_ FPSSA 1231_ FLRAK 1236_ EEQQD 1241_ DTVYM 1246_ GKVTF 1251_ SCAAG 1256_ FGQRH 1261_ RLVLT 1266_ QEQLH 1271_QLHSR
1: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020)