Translation initiation factor eIF-2B subunit alpha (eIF-2B GDP-GTP exchange factor subunit alpha)
1_MDDKE 6_ LIEYF 11_ KSQMK 16_ EDPDM 21_ ASAVA 26_ AIRTL 31_ LEFLK 36_ RDKGE 41_ TIQGL 46_ RANLT 51_ SAIET 56_ LCGVD 61_ SSVAV 66_ SSGGE 71_ LFLRF 76_ ISLAS 81_ LEYSD 86_ YSKCK 91_ KIMIE 96_ RGELF 101_ LRRIS 106_ LSRNK 111_ IADLC 116_ HTFIK 121_ DGATI 126_ LTHAY 131_ SRVVL 136_ RVLEA 141_ AVAAK 146_ KRFSV 151_ YVTES 156_ QPDLS 161_ GKKMA 166_ KALCH 171_ LNVPV 176_ TVVLD 181_ AAVGY 186_ IMEKA 191_ DLVIV 196_ GAEGV 201_ VENGG 206_ IINKI 211_ GTNQM 216_ AVCAK 221_ AQNKP 226_ FYVVA 231_ ESFKF 236_ VRLFP 241_ LNQQD 246_ VPDKF 251_ KYKAD 256_ TLKVA 261_ QTGQD 266_ LKEEH 271_ PWVDY 276_ TAPSL 281_ ITLLF 286_ TDLGV 291_ LTPSA 296_VSDEL
1: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492)