Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
1_MSGGS 6_ ADYNR 11_ EHGGP 16_ EGMDP 21_ DGVIE 26_ SNWNE 31_ IVDNF 36_ DDMNL 41_ KESLL 46_ RGIYA 51_ YGFEK 56_ PSAIQ 61_ QRAII 66_ PCIKG 71_ YDVIA 76_ QAQSG 81_ TGKTA 86_ TFAIS 91_ ILQQL 96_ EIEFK 101_ ETQAL 106_ VLAPT 111_ RELAQ 116_ QIQKV 121_ ILALG 126_ DYMGA 131_ TCHAC 136_ IGGTN 141_ VRNEM 146_ QKLQA 151_ EAPHI 156_ VVGTP 161_ GRVFD 166_ MLNRR 171_ YLSPK 176_ WIKMF 181_ VLDEA 186_ DEMLS 191_ RGFKD 196_ QIYEI 201_ FQKLN 206_ TSIQV 211_ VLLSA 216_ TMPTD 221_ VLEVT 226_ KKFMR 231_ DPIRI 236_ LVKKE 241_ ELTLE 246_ GIKQF 251_ YINVE 256_ REEWK 261_ LDTLC 266_ DLYET 271_ LTITQ 276_ AVIFL 281_ NTRRK 286_ VDWLT 291_ EKMHA 296_ RDFTV 301_ SALHG 306_ DMDQK 311_ ERDVI 316_ MREFR 321_ SGSSR 326_ VLITT 331_ DLLAR 336_ GIDVQ 341_ QVSLV 346_ INYDL 351_ PTNRE 356_ NYIHR 361_ IGRGG 366_ RFGRK 371_ GVAIN 376_ FVTEE 381_ DKRIL 386_ RDIET 391_ FYNTT 396_ VEEMP 401_MNVAD
1: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon