Src substrate cortactin (Amplaxin) (Oncogene EMS1)
1_MWKAS 6_ AGHAV 11_ SIAQD 16_ DAGAD 21_ DWETD 26_ PDFVN 31_ DVSEK 36_ EQRWG 41_ AKTVQ 46_ GSGHQ 51_ EHINI 56_ HKLRE 61_ NVFQE 66_ HQTLK 71_ EKELE 76_ TGPKA 81_ SHGYG 86_ GKFGV 91_ EQDRM 96_ DKSAV 101_ GHEYQ 106_ SKLSK 111_ HCSQV 116_ DSVRG 121_ FGGKF 126_ GVQMD 131_ RVDQS 136_ AVGFE 141_ YQGKT 146_ EKHAS 151_ QKDYS 156_ SGFGG 161_ KYGVQ 166_ ADRVD 171_ KSAVG 176_ FDYQG 181_ KTEKH 186_ ESQRD 191_ YSKGF 196_ GGKYG 201_ IDKDK 206_ VDKSA 211_ VGFEY 216_ QGKTE 221_ KHESQ 226_ KDYVK 231_ GFGGK 236_ FGVQT 241_ DRQDK 246_ CALGW 251_ DHQEK 256_ LQLHE 261_ SQKDY 266_ KTGFG 271_ GKFGV 276_ QSERQ 281_ DSAAV 286_ GFDYK 291_ EKLAK 296_ HESQQ 301_ DYSKG 306_ FGGKY 311_ GVQKD 316_ RMDKN 321_ ASTFE 326_ DVTQV 331_ SSAYQ 336_ KTVPV 341_ EAVTS 346_ KTSNI 351_ RANFE 356_ NLAKE 361_ KEQED 366_ RRKAE 371_ AERAQ 376_ RMAKE 381_ RQEQE 386_ EARRK 391_ LEEQA 396_ RAKTQ 401_ TPPVS 406_ PAPQP 411_ TEERL 416_ PSSPV 421_ YEDAA 426_ SFKAE 431_ LSYRG 436_ PVSGT 441_ EPEPV 446_ YSMEA 451_ ADYRE 456_ ASSQQ 461_ GLAYA 466_ TEAVY 471_ ESAEA 476_ PGHYP 481_ AEDST 486_ YDEYE 491_ NDLGI 496_ TAVAL 501_ YDYQA 506_ AGDDE 511_ ISFDP 516_ DDIIT 521_ NIEMI 526_ DDGWW 531_ RGVCK 536_ GRYGL 541_FPANY
1: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290)