E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
1_MAELC 6_ PLAEE 11_ LSCSI 16_ CLEPF 21_ KEPVT 26_ TPCGH 31_ NFCGS 36_ CLNET 41_ WAVQG 46_ SPYLC 51_ PQCRA 56_ VYQAR 61_ PQLHK 66_ NTVLC 71_ NVVEQ 76_ FLQAD 81_ LAREP 86_ PADVW 91_ TPPAR 96_ ASAPS 101_ PNAQV 106_ ACDHC 111_ LKEAA 116_ VKTCL 121_ VCMAS 126_ FCQEH 131_ LQPHF 136_ DSPAF 141_ QDHPL 146_ QPPVR 151_ DLLRR 156_ KCSQH 161_ NRLRE 166_ FFCPE 171_ HSECI 176_ CHICL 181_ VEHKT 186_ CSPAS 191_ LSQAS 196_ ADLEA 201_ TLRHK 206_ LTVMY 211_ SQING 216_ ASRAL 221_ DDVRN 226_ RQQDV 231_ RMTAN 236_ RKVEQ 241_ LQQEY 246_ TEMKA 251_ LLDAS 256_ ETTST 261_ RKIKE 266_ EEKRV 271_ NSKFD 276_ TIYQI 281_ LLKKK 286_ SEIQT 291_ LKEEI 296_ EQSLT 301_ KRDEF 306_ EFLEK 311_ ASKLR 316_ GISTK 321_ PVYIP 326_ EVELN 331_ HKLIK 336_ GIHQS 341_ TIDLK 346_ NELKQ 351_ CIGRL 356_ QEPTP 361_ SSGDP 366_ GEHDP 371_ ASTHK 376_ STRPV 381_ KKVSK 386_ EEKKS 391_ KKPPP 396_ VPALP 401_ SKLPT 406_ FGAPE 411_ QLVDL 416_ KQAGL 421_ EAAAK 426_ ATSSH 431_ PNSTS 436_ LKAKV 441_ LETFL 446_ AKSRP 451_ ELLEY 456_ YIKVI 461_ LDYNT 466_ AHNKV 471_ ALSEC 476_ YTVAS 481_ VAEMP 486_ QNYRP 491_ HPQRF 496_ TYCSQ 501_ VLGLH 506_ CYKKG 511_ IHYWE 516_ VELQK 521_ NNFCG 526_ VGICY 531_ GSMNR 536_ QGPES 541_ RLGRN 546_ SASWC 551_ VEWFN 556_ TKISA 561_ WHNNV 566_ EKTLP 571_ STKAT 576_ RVGVL 581_ LNCDH 586_ GFVIF 591_ FAVAD 596_ KVHLM 601_ YKFRV 606_ DFTEA 611_ LYPAF 616_ WVFSA 621_GATLS
1: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236)