Endogenous retrovirus group 3 member 1 Env polyprotein (ERV-3 envelope protein) (ERV3 envelope protein) (ERV3-1 envelope protein) (Envelope polyprotein) (HERV-R envelope protein) (ERV-R envelope protein) (HERV-R_7q21.2 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]
1_MLGMN 6_ MLLIT 11_ LFLLL 16_ PLSML 21_ KGEPW 26_ EGCLH 31_ CTHTT 36_ WSGNI 41_ MTKTL 46_ LYHTY 51_ YECAG 56_ TCLGT 61_ CTHNQ 66_ TTYSV 71_ CDPGR 76_ GQPYV 81_ CYDPK 86_ SSPGT 91_ WFEIH 96_ VGSKE 101_ GDLLN 106_ QTKVF 111_ PSGKD 116_ VVSLY 121_ FDVCQ 126_ IVSMG 131_ SLFPV 136_ IFSSM 141_ EYYSS 146_ CHKNR 151_ YAHPA 156_ CSTDS 161_ PVTTC 166_ WDCTT 171_ WSTNQ 176_ QSLGP 181_ IMLTK 186_ IPLEP 191_ DCKTS 196_ TCNSV 201_ NLTIL 206_ EPDQP 211_ IWTTG 216_ LKAPL 221_ GARVS 226_ GEEIG 231_ PGAYV 236_ YLYII 241_ KKTRT 246_ RSTQQ 251_ FRVFE 256_ SFYEH 261_ VNQKL 266_ PEPPP 271_ LASNL 276_ FAQLA 281_ ENIAS 286_ SLHVA 291_ SCYVC 296_ GGMNM 301_ GDQWP 306_ WEARE 311_ LMPQD 316_ NFTLT 321_ ASSLE 326_ PAPSS 331_ QSIWF 336_ LKTSI 341_ IGKFC 346_ IARWG 351_ KAFTD 356_ PVGEL 361_ TCLGQ 366_ QYYNE 371_ TLGKT 376_ LWRGK 381_ SNNSE 386_ SPHPS 391_ PFSRF 396_ PSLNH 401_ SWYQL 406_ EAPNT 411_ WQAPS 416_ GLYWI 421_ CGPQA 426_ YRQLP 431_ AKWSG 436_ ACVLG 441_ TIRPS 446_ FFLMP 451_ LKQGE 456_ ALGYP 461_ IYDET 466_ KRKSK 471_ RGITI 476_ GDWKD 481_ NEWPP 486_ ERIIQ 491_ YYGPA 496_ TWAED 501_ GMWGY 506_ RTPVY 511_ MLNRI 516_ IRLQA 521_ VLEII 526_ TNETA 531_ GALNL 536_ LAQQA 541_ TKMRN 546_ VIYQN 551_ RLALD 556_ YLLAQ 561_ EEGVC 566_ GKFNL 571_ TNCCL 576_ ELDDE 581_ GKVIK 586_ EITAK 591_ IQKLA 596_HIPVQ
1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro
2: SU mediates receptor recognition
3: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity)