Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
1_MSGVS 6_ EPLSR 11_ VKLGT 16_ LRRPE 21_ GPAEP 26_ MVVVP 31_ VDVEK 36_ EDVRI 41_ LKVCF 46_ YSNSF 51_ NPGKN 56_ FKLVK 61_ CTVQT 66_ EIREI 71_ ITSIL 76_ LSGRI 81_ GPNIR 86_ LAECY 91_ GLRLK 96_ HMKSD 101_ EIHWL 106_ HPQMT 111_ VGEVQ 116_ DKYEC 121_ LHVEA 126_ EWRYD 131_ LQIRY 136_ LPEDF 141_ MESLK 146_ EDRTT 151_ LLYFY 156_ QQLRN 161_ DYMQR 166_ YASKV 171_ SEGMA 176_ LQLGC 181_ LELRR 186_ FFKDM 191_ PHNAL 196_ DKKSN 201_ FELLE 206_ KEVGL 211_ DLFFP 216_ KQMQE 221_ NLKPK 226_ QFRKM 231_ IQQTF 236_ QQYAS 241_ LREEE 246_ CVMKF 251_ FNTLA 256_ GFANI 261_ DQETY 266_ RCELI 271_ QGWNI 276_ TVDLV 281_ IGPKG 286_ IRQLT 291_ SQDAK 296_ PTCLA 301_ EFKQI 306_ RSIRC 311_ LPLEE 316_ GQAVL 321_ QLGIE 326_ GAPQA 331_ LSIKT 336_ SSLAE 341_ AENMA 346_ DLIDG 351_ YCRLQ 356_ GEHQG 361_ SLIIH 366_ PRKDG 371_ EKRNS 376_ LPQIP 381_ MLNLE 386_ ARRSH 391_ LSESC 396_ SIESD 401_ IYAEI 406_ PDETL 411_ RRPGG 416_ PQYGI 421_ AREDV 426_ VLNRI 431_ LGEGF 436_ FGEVY 441_ EGVYT 446_ NHKGE 451_ KINVA 456_ VKTCK 461_ KDCTL 466_ DNKEK 471_ FMSEA 476_ VIMKN 481_ LDHPH 486_ IVKLI 491_ GIIEE 496_ EPTWI 501_ IMELY 506_ PYGEL 511_ GHYLE 516_ RNKNS 521_ LKVLT 526_ LVLYS 531_ LQICK 536_ AMAYL 541_ ESINC 546_ VHRDI 551_ AVRNI 556_ LVASP 561_ ECVKL 566_ GDFGL 571_ SRYIE 576_ DEDYY 581_ KASVT 586_ RLPIK 591_ WMSPE 596_ SINFR 601_ RFTTA 606_ SDVWM 611_ FAVCM 616_ WEILS 621_ FGKQP 626_ FFWLE 631_ NKDVI 636_ GVLEK 641_ GDRLP 646_ KPDLC 651_ PPVLY 656_ TLMTR 661_ CWDYD 666_ PSDRP 671_ RFTEL 676_ VCSLS 681_ DVYQM 686_ EKDIA 691_ MEQER 696_ NARYR 701_ TPKIL 706_ EPTAF 711_ QEPPP 716_ KPSRP 721_ KYRPP 726_ PQTNL 731_ LAPKL 736_ QFQVP 741_ EGLCA 746_ SSPTL 751_ TSPME 756_ YPSPV 761_ NSLHT 766_ PPLHR 771_ HNVFK 776_ RHSMR 781_ EEDFI 786_ QPSSR 791_ EEAQQ 796_ LWEAE 801_ KVKMR 806_ QILDK 811_ QQKQM 816_ VEDYQ 821_ WLRQE 826_ EKSLD 831_ PMVYM 836_ NDKSP 841_ LTPEK 846_ EVGYL 851_ EFTGP 856_ PQKPP 861_ RLGAQ 866_ SIQPT 871_ ANLDR 876_ TDDLV 881_ YLNVM 886_ ELVRA 891_ VLELK 896_ NELCQ 901_ LPPEG 906_ YVVVV 911_ KNVGL 916_ TLRKL 921_ IGSVD 926_ DLLPS 931_ LPSSS 936_ RTEIE 941_ GTQKL 946_ LNKDL 951_ AELIN 956_ KMRLA 961_ QQNAV 966_ TSLSE 971_ ECKRQ 976_ MLTAS 981_ HTLAV 986_ DAKNL 991_ LDAVD 996_ QAKVL 1001_ANLAH
1: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2