Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)
1_MASCA 6_ EPSEP 11_ SAPLP 16_ AGVPP 21_ LEDFE 26_ VLDGV 31_ EDAEG 36_ EEEEE 41_ EEEEE 46_ EDDLS 51_ ELPPL 56_ EDMGQ 61_ PPAEE 66_ AEQPG 71_ ALARE 76_ FLAAM 81_ EPEPA 86_ PAPAP 91_ EEWLD 96_ ILGNG 101_ LLRKK 106_ TLVPG 111_ PPGSS 116_ RPVKG 121_ QVVTV 126_ HLQTS 131_ LENGT 136_ RVQEE 141_ PELVF 146_ TLGDC 151_ DVIQA 156_ LDLSV 161_ PLMDV 166_ GETAM 171_ VTADS 176_ KYCYG 181_ PQGRS 186_ PYIPP 191_ HAALC 196_ LEVTL 201_ KTAVD 206_ GPDLE 211_ MLTGQ 216_ ERVAL 221_ ANRKR 226_ ECGNA 231_ HYQRA 236_ DFVLA 241_ ANSYD 246_ LAIKA 251_ ITSSA 256_ KVDMT 261_ FEEEA 266_ QLLQL 271_ KVKCL 276_ NNLAA 281_ SQLKL 286_ DHYRA 291_ ALRSC 296_ SLVLE 301_ HQPDN 306_ IKALF 311_ RKGKV 316_ LAQQG 321_ EYSEA 326_ IPILR 331_ AALKL 336_ EPSNK 341_ TIHAE 346_ LSKLV 351_ KKHAA 356_ QRSTE 361_ TALYR 366_ KMLGN 371_ PSRLP 376_ AKCPG 381_ KGAWS 386_ IPWKW 391_ LFGAT 396_ AVALG 401_ GVALS 406_VVIAA
1: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297)