N-arachidonyl glycine receptor (NAGly receptor) (G-protein coupled receptor 18)
1_MITLN 6_ NQDQP 11_ VPFNS 16_ SHPDE 21_ YKIAA 26_ LVFYS 31_ CIFII 36_ GLFVN 41_ ITALW 46_ VFSCT 51_ TKKRT 56_ TVTIY 61_ MMNVA 66_ LVDLI 71_ FIMTL 76_ PFRMF 81_ YYAKD 86_ EWPFG 91_ EYFCQ 96_ ILGAL 101_ TVFYP 106_ SIALW 111_ LLAFI 116_ SADRY 121_ MAIVQ 126_ PKYAK 131_ ELKNT 136_ CKAVL 141_ ACVGV 146_ WIMTL 151_ TTTTP 156_ LLLLY 161_ KDPDK 166_ DSTPA 171_ TCLKI 176_ SDIIY 181_ LKAVN 186_ VLNLT 191_ RLTFF 196_ FLIPL 201_ FIMIG 206_ CYLVI 211_ IHNLL 216_ HGRTS 221_ KLKPK 226_ VKEKS 231_ IRIII 236_ TLLVQ 241_ VLVCF 246_ MPFHI 251_ CFAFL 256_ MLGTG 261_ ENSYN 266_ PWGAF 271_ TTFLM 276_ NLSTC 281_ LDVIL 286_ YYIVS 291_ KQFQA 296_ RVISV 301_ MLYRN 306_ YLRSM 311_ RRKSF 316_ RSGSL 321_ RSLSN 326_INSEM
1: G protein-coupled receptor (GPCR) that plays a role in diverse physiological processes particularly within the immune and nervous systems (PubMed:21732409, PubMed:26195725). Becomes active when triggered by various endogenous ligands including endocannabinoid N-arachidonyl glycine (NAGly), delta-9-tetrahydrocannabinol or resolvin D2/RvD2 derived from the omega-3 fatty acid docosahexaenoic acid (DHA) (PubMed:16844083, PubMed:24762058, PubMed:26195725, PubMed:27572937). Upon RvD2 binding, facilitates the resolution of inflammation, aiding in tissue repair and homeostasis. Mechanistically, RvD2 ligation initiates Galphas protein coupling, activation of cAMP-PKA signaling pathway and phosphorylation of STAT3, leading to RvD2-stimulated macrophage phagocytosis (PubMed:27994074). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937). Activation by N-arachidonoyl glycine (NAGly) can also induce apoptosis in macrophages (By similarity). Plays a role in homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intestine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Also participates in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity)