Frizzled-2 (Fz-2) (hFz2) (FzE2)
1_MRPRS 6_ ALPRL 11_ LLPLL 16_ LLPAA 21_ GPAQF 26_ HGEKG 31_ ISIPD 36_ HGFCQ 41_ PISIP 46_ LCTDI 51_ AYNQT 56_ IMPNL 61_ LGHTN 66_ QEDAG 71_ LEVHQ 76_ FYPLV 81_ KVQCS 86_ PELRF 91_ FLCSM 96_ YAPVC 101_ TVLEQ 106_ AIPPC 111_ RSICE 116_ RARQG 121_ CEALM 126_ NKFGF 131_ QWPER 136_ LRCEH 141_ FPRHG 146_ AEQIC 151_ VGQNH 156_ SEDGA 161_ PALLT 166_ TAPPP 171_ GLQPG 176_ AGGTP 181_ GGPGG 186_ GGAPP 191_ RYATL 196_ EHPFH 201_ CPRVL 206_ KVPSY 211_ LSYKF 216_ LGERD 221_ CAAPC 226_ EPARP 231_ DGSMF 236_ FSQEE 241_ TRFAR 246_ LWILT 251_ WSVLC 256_ CASTF 261_ FTVTT 266_ YLVDM 271_ QRFRY 276_ PERPI 281_ IFLSG 286_ CYTMV 291_ SVAYI 296_ AGFVL 301_ QERVV 306_ CNERF 311_ SEDGY 316_ RTVVQ 321_ GTKKE 326_ GCTIL 331_ FMMLY 336_ FFSMA 341_ SSIWW 346_ VILSL 351_ TWFLA 356_ AGMKW 361_ GHEAI 366_ EANSQ 371_ YFHLA 376_ AWAVP 381_ AVKTI 386_ TILAM 391_ GQIDG 396_ DLLSG 401_ VCFVG 406_ LNSLD 411_ PLRGF 416_ VLAPL 421_ FVYLF 426_ IGTSF 431_ LLAGF 436_ VSLFR 441_ IRTIM 446_ KHDGT 451_ KTEKL 456_ ERLMV 461_ RIGVF 466_ SVLYT 471_ VPATI 476_ VIACY 481_ FYEQA 486_ FREHW 491_ ERSWV 496_ SQHCK 501_ SLAIP 506_ CPAHY 511_ TPRMS 516_ PDFTV 521_ YMIKY 526_ LMTLI 531_ VGITS 536_ GFWIW 541_ SGKTL 546_ HSWRK 551_ FYTRL 556_TNSRH
1: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:25759469). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues
2: (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium (PubMed:27680706, PubMed:29748286). TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling (PubMed:29748286)