Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13)
1_MADFL 6_ PSRSV 11_ LSVCF 16_ PGCLL 21_ TSGEA 26_ EQQRK 31_ SKEID 36_ KCLSR 41_ EKTYV 46_ KRLVK 51_ ILLLG 56_ AGESG 61_ KSTFL 66_ KQMRI 71_ IHGQD 76_ FDQRA 81_ REEFR 86_ PTIYS 91_ NVIKG 96_ MRVLV 101_ DAREK 106_ LHIPW 111_ GDNSN 116_ QQHGD 121_ KMMSF 126_ DTRAP 131_ MAAQG 136_ MVETR 141_ VFLQY 146_ LPAIR 151_ ALWAD 156_ SGIQN 161_ AYDRR 166_ REFQL 171_ GESVK 176_ YFLDN 181_ LDKLG 186_ EPDYI 191_ PSQQD 196_ ILLAR 201_ RPTKG 206_ IHEYD 211_ FEIKN 216_ VPFKM 221_ VDVGG 226_ QRSER 231_ KRWFE 236_ CFDSV 241_ TSILF 246_ LVSSS 251_ EFDQV 256_ LMEDR 261_ LTNRL 266_ TESLN 271_ IFETI 276_ VNNRV 281_ FSNVS 286_ IILFL 291_ NKTDL 296_ LEEKV 301_ QIVSI 306_ KDYFL 311_ EFEGD 316_ PHCLR 321_ DVQKF 326_ LVECF 331_ RNKRR 336_ DQQQK 341_ PLYHH 346_ FTTAI 351_ NTENI 356_ RLVFR 361_ DVKDT 366_ ILHDN 371_LKQLM
1: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16705036, PubMed:16787920, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:12515866, PubMed:15240885). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16705036, PubMed:16787920, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in a process independent from Rho activation (PubMed:11976333). In lymphoid follicles, transmits P2RY8- and S1PR2-dependent signals that lead to inhibition of germinal center (GC) B cell growth and migration outside the GC niche