UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase)
1_MAEKV 6_ LVTGG 11_ AGYIG 16_ SHTVL 21_ ELLEA 26_ GYLPV 31_ VIDNF 36_ HNAFR 41_ GGGSL 46_ PESLR 51_ RVQEL 56_ TGRSV 61_ EFEEM 66_ DILDQ 71_ GALQR 76_ LFKKY 81_ SFMAV 86_ IHFAG 91_ LKAVG 96_ ESVQK 101_ PLDYY 106_ RVNLT 111_ GTIQL 116_ LEIMK 121_ AHGVK 126_ NLVFS 131_ SSATV 136_ YGNPQ 141_ YLPLD 146_ EAHPT 151_ GGCTN 156_ PYGKS 161_ KFFIE 166_ EMIRD 171_ LCQAD 176_ KTWNA 181_ VLLRY 186_ FNPTG 191_ AHASG 196_ CIGED 201_ PQGIP 206_ NNLMP 211_ YVSQV 216_ AIGRR 221_ EALNV 226_ FGNDY 231_ DTEDG 236_ TGVRD 241_ YIHVV 246_ DLAKG 251_ HIAAL 256_ RKLKE 261_ QCGCR 266_ IYNLG 271_ TGTGY 276_ SVLQM 281_ VQAME 286_ KASGK 291_ KIPYK 296_ VVARR 301_ EGDVA 306_ ACYAN 311_ PSLAQ 316_ EELGW 321_ TAALG 326_ LDRMC 331_ EDLWR 336_ WQKQN 341_PSGFG
1: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids