Transforming growth factor beta activator LRRC32 (Garpin) (Glycoprotein A repetitions predominant) (GARP) (Leucine-rich repeat-containing protein 32)
1_MRPQI 6_ LLLLA 11_ LLTLG 16_ LAAQH 21_ QDKVP 26_ CKMVD 31_ KKVSC 36_ QVLGL 41_ LQVPS 46_ VLPPD 51_ TETLD 56_ LSGNQ 61_ LRSIL 66_ ASPLG 71_ FYTAL 76_ RHLDL 81_ STNEI 86_ SFLQP 91_ GAFQA 96_ LTHLE 101_ HLSLA 106_ HNRLA 111_ MATAL 116_ SAGGL 121_ GPLPR 126_ VTSLD 131_ LSGNS 136_ LYSGL 141_ LERLL 146_ GEAPS 151_ LHTLS 156_ LAENS 161_ LTRLT 166_ RHTFR 171_ DMPAL 176_ EQLDL 181_ HSNVL 186_ MDIED 191_ GAFEG 196_ LPRLT 201_ HLNLS 206_ RNSLT 211_ CISDF 216_ SLQQL 221_ RVLDL 226_ SCNSI 231_ EAFQT 236_ ASQPQ 241_ AEFQL 246_ TWLDL 251_ RENKL 256_ LHFPD 261_ LAALP 266_ RLIYL 271_ NLSNN 276_ LIRLP 281_ TGPPQ 286_ DSKGI 291_ HAPSE 296_ GWSAL 301_ PLSAP 306_ SGNAS 311_ GRPLS 316_ QLLNL 321_ DLSYN 326_ EIELI 331_ PDSFL 336_ EHLTS 341_ LCFLN 346_ LSRNC 351_ LRTFE 356_ ARRLG 361_ SLPCL 366_ MLLDL 371_ SHNAL 376_ ETLEL 381_ GARAL 386_ GSLRT 391_ LLLQG 396_ NALRD 401_ LPPYT 406_ FANLA 411_ SLQRL 416_ NLQGN 421_ RVSPC 426_ GGPDE 431_ PGPSG 436_ CVAFS 441_ GITSL 446_ RSLSL 451_ VDNEI 456_ ELLRA 461_ GAFLH 466_ TPLTE 471_ LDLSS 476_ NPGLE 481_ VATGA 486_ LGGLE 491_ ASLEV 496_ LALQG 501_ NGLMV 506_ LQVDL 511_ PCFIC 516_ LKRLN 521_ LAENR 526_ LSHLP 531_ AWTQA 536_ VSLEV 541_ LDLRN 546_ NSFSL 551_ LPGSA 556_ MGGLE 561_ TSLRR 566_ LYLQG 571_ NPLSC 576_ CGNGW 581_ LAAQL 586_ HQGRV 591_ DVDAT 596_ QDLIC 601_ RFSSQ 606_ EEVSL 611_ SHVRP 616_ EDCEK 621_ GGLKN 626_ INLII 631_ ILTFI 636_ LVSAI 641_ LLTTL 646_ AACCC 651_ VRRQK 656_FNQQY
1: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19651619, PubMed:19750484, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19651619, PubMed:19750484). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity)