Glucokinase regulatory protein (GKRP) (Glucokinase regulator)
1_MPGTK 6_ RFQHV 11_ IETPE 16_ PGKWE 21_ LSGYE 26_ AAVPI 31_ TEKSN 36_ PLTQD 41_ LDKAD 46_ AENIV 51_ RLLGQ 56_ CDAEI 61_ FQEEG 66_ QALST 71_ YQRLY 76_ SESIL 81_ TTMVQ 86_ VAGKV 91_ QEVLK 96_ EPDGG 101_ LVVLS 106_ GGGTS 111_ GRMAF 116_ LMSVS 121_ FNQLM 126_ KGLGQ 131_ KPLYT 136_ YLIAG 141_ GDRSV 146_ VASRE 151_ GTEDS 156_ ALHGI 161_ EELKK 166_ VAAGK 171_ KRVIV 176_ IGISV 181_ GLSAP 186_ FVAGQ 191_ MDCCM 196_ NNTAV 201_ FLPVL 206_ VGFNP 211_ VSMAR 216_ NDPIE 221_ DWSST 226_ FRQVA 231_ ERMQK 236_ MQEKQ 241_ KAFVL 246_ NPAIG 251_ PEGLS 256_ GSSRM 261_ KGGSA 266_ TKILL 271_ ETLLL 276_ AAHKT 281_ VDQGI 286_ AASQR 291_ CLLEI 296_ LRTFE 301_ RAHQV 306_ TYSQS 311_ PKIAT 316_ LMKSV 321_ STSLE 326_ KKGHV 331_ YLVGW 336_ QTLGI 341_ IAIMD 346_ GVECI 351_ HTFGA 356_ DFRDV 361_ RGFLI 366_ GDHSD 371_ MFNQK 376_ AELTN 381_ QGPQF 386_ TFSQE 391_ DFLTS 396_ ILPSL 401_ TEIDT 406_ VVFIF 411_ TLDDN 416_ LTEVQ 421_ TIVEQ 426_ VKEKT 431_ NHIQA 436_ LAHST 441_ VGQTL 446_ PIPLK 451_ KLFPS 456_ IISIT 461_ WPLLF 466_ FEYEG 471_ NFIQK 476_ FQREL 481_ STKWV 486_ LNTVS 491_ TGAHV 496_ LLGKI 501_ LQNHM 506_ LDLRI 511_ SNSKL 516_ FWRAL 521_ AMLQR 526_ FSGQS 531_ KARCI 536_ ESLLR 541_ AIHFP 546_ QPLSD 551_ DIRAA 556_ PISCH 561_ VQVAH 566_ EKEQV 571_ IPIAL 576_ LSLLF 581_ RCSIT 586_ EAQAH 591_ LAAAP 596_ SVCEA 601_ VRSAL 606_ AGPGQ 611_ KRTAD 616_PLEIL
1: Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23621087, PubMed:23733961). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23621087, PubMed:23733961)