Metabotropic glutamate receptor 2 (mGluR2)
1_MGSLL 6_ ALLAL 11_ LLLWG 16_ AVAEG 21_ PAKKV 26_ LTLEG 31_ DLVLG 36_ GLFPV 41_ HQKGG 46_ PAEDC 51_ GPVNE 56_ HRGIQ 61_ RLEAM 66_ LFALD 71_ RINRD 76_ PHLLP 81_ GVRLG 86_ AHILD 91_ SCSKD 96_ THALE 101_ QALDF 106_ VRASL 111_ SRGAD 116_ GSRHI 121_ CPDGS 126_ YATHG 131_ DAPTA 136_ ITGVI 141_ GGSYS 146_ DVSIQ 151_ VANLL 156_ RLFQI 161_ PQISY 166_ ASTSA 171_ KLSDK 176_ SRYDY 181_ FARTV 186_ PPDFF 191_ QAKAM 196_ AEILR 201_ FFNWT 206_ YVSTV 211_ ASEGD 216_ YGETG 221_ IEAFE 226_ LEARA 231_ RNICV 236_ ATSEK 241_ VGRAM 246_ SRAAF 251_ EGVVR 256_ ALLQK 261_ PSARV 266_ AVLFT 271_ RSEDA 276_ RELLA 281_ ASQRL 286_ NASFT 291_ WVASD 296_ GWGAL 301_ ESVVA 306_ GSEGA 311_ AEGAI 316_ TIELA 321_ SYPIS 326_ DFASY 331_ FQSLD 336_ PWNNS 341_ RNPWF 346_ REFWE 351_ QRFRC 356_ SFRQR 361_ DCAAH 366_ SLRAV 371_ PFEQE 376_ SKIMF 381_ VVNAV 386_ YAMAH 391_ ALHNM 396_ HRALC 401_ PNTTR 406_ LCDAM 411_ RPVNG 416_ RRLYK 421_ DFVLN 426_ VKFDA 431_ PFRPA 436_ DTHNE 441_ VRFDR 446_ FGDGI 451_ GRYNI 456_ FTYLR 461_ AGSGR 466_ YRYQK 471_ VGYWA 476_ EGLTL 481_ DTSLI 486_ PWASP 491_ SAGPL 496_ PASRC 501_ SEPCL 506_ QNEVK 511_ SVQPG 516_ EVCCW 521_ LCIPC 526_ QPYEY 531_ RLDEF 536_ TCADC 541_ GLGYW 546_ PNASL 551_ TGCFE 556_ LPQEY 561_ IRWGD 566_ AWAVG 571_ PVTIA 576_ CLGAL 581_ ATLFV 586_ LGVFV 591_ RHNAT 596_ PVVKA 601_ SGREL 606_ CYILL 611_ GGVFL 616_ CYCMT 621_ FIFIA 626_ KPSTA 631_ VCTLR 636_ RLGLG 641_ TAFSV 646_ CYSAL 651_ LTKTN 656_ RIARI 661_ FGGAR 666_ EGAQR 671_ PRFIS 676_ PASQV 681_ AICLA 686_ LISGQ 691_ LLIVV 696_ AWLVV 701_ EAPGT 706_ GKETA 711_ PERRE 716_ VVTLR 721_ CNHRD 726_ ASMLG 731_ SLAYN 736_ VLLIA 741_ LCTLY 746_ AFKTR 751_ KCPEN 756_ FNEAK 761_ FIGFT 766_ MYTTC 771_ IIWLA 776_ FLPIF 781_ YVTSS 786_ DYRVQ 791_ TTTMC 796_ VSVSL 801_ SGSVV 806_ LGCLF 811_ APKLH 816_ IILFQ 821_ PQKNV 826_ VSHRA 831_ PTSRF 836_ GSAAA 841_ RASSS 846_ LGQGS 851_ GSQFV 856_ PTVCN 861_ GREVV 866_DSTTS
1: Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (By similarity). Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization
2: (Microbial infection) Plays an important role in influenza virus internalization
3: (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of GRM2 to enter cells
4: (Microbial infection) Acts as a host entry factor for SARS-CoV-2 that hijacks the endocytosis of GRM2 to enter cells