cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)
1_MAVPG 6_ DAARV 11_ RDKPV 16_ HSGVS 21_ QAPTA 26_ GRDCH 31_ HRADP 36_ ASPRD 41_ SGCRG 46_ CWGDL 51_ VLQPL 56_ RSSRK 61_ LSSAL 66_ CAGSL 71_ SFLLA 76_ LLVRL 81_ VRGEV 86_ GCDLE 91_ QCKEA 96_ AAAEE 101_ EEAAP 106_ GAEGG 111_ VFPGP 116_ RGGAP 121_ GGGAR 126_ LSPWL 131_ QPSAL 136_ LFSLL 141_ CAFFW 146_ MGLYL 151_ LRAGV 156_ RLPLA 161_ VALLA 166_ ACCGG 171_ EALVQ 176_ IGLGV 181_ GEDHL 186_ LSLPA 191_ AGVVL 196_ SCLAA 201_ ATWLV 206_ LRLRL 211_ GVLMI 216_ ALTSA 221_ VRTVS 226_ LISLE 231_ RFKVA 236_ WRPYL 241_ AYLAG 246_ VLGIL 251_ LARYV 256_ EQILP 261_ QSAEA 266_ APREH 271_ LGSQL 276_ IAGTK 281_ EDIPV 286_ FKRRR 291_ RSSSV 296_ VSAEM 301_ SGCSS 306_ KSHRR 311_ TSLPC 316_ IPREQ 321_ LMGHS 326_ EWDHK 331_ RGPRG 336_ SQSSG 341_ TSITV 346_ DIAVM 351_ GEAHG 356_ LITDL 361_ LADPS 366_ LPPNV 371_ CTSLR 376_ AVSNL 381_ LSTQL 386_ TFQAI 391_ HKPRV 396_ NPVTS 401_ LSENY 406_ TCSDS 411_ EESSE 416_ KDKLA 421_ IPKRL 426_ RRSLP 431_ PGLLR 436_ RVSST 441_ WTTTT 446_ SATGL 451_ PTLEP 456_ APVRR 461_ DRSTS 466_ IKLQE 471_ APSSS 476_ PDSWN 481_ NPVMM 486_ TLTKS 491_ RSFTS 496_ SYAIS 501_ AANHV 506_ KAKKQ 511_ SRPGA 516_ LAKIS 521_ PLSSP 526_ CSSPL 531_ QGTPA 536_ SSLVS 541_ KISAV 546_ QFPES 551_ ADTTA 556_ KQSLG 561_ SHRAL 566_ TYTQS 571_ APDLS 576_ PQILT 581_ PPVIC 586_ SSCGR 591_ PYSQG 596_ NPADE 601_ PLERS 606_ GVATR 611_ TPSRT 616_ DDTAQ 621_ VTSDY 626_ ETNNN 631_ SDSSD 636_ IVQNE 641_ DETEC 646_ LREPL 651_ RKASA 656_ CSTYA 661_ PETMM 666_ FLDKP 671_ ILAPE 676_ PLVMD 681_ NLDSI 686_ MEQLN 691_ TWNFP 696_ IFDLV 701_ ENIGR 706_ KCGRI 711_ LSQVS 716_ YRLFE 721_ DMGLF 726_ EAFKI 731_ PIREF 736_ MNYFH 741_ ALEIG 746_ YRDIP 751_ YHNRI 756_ HATDV 761_ LHAVW 766_ YLTTQ 771_ PIPGL 776_ STVIN 781_ DHGST 786_ SDSDS 791_ DSGFT 796_ HGHMG 801_ YVFSK 806_ TYNVT 811_ DDKYG 816_ CLSGN 821_ IPALE 826_ LMALY 831_ VAAAM 836_ HDYDH 841_ PGRTN 846_ AFLVA 851_ TSAPQ 856_ AVLYN 861_ DRSVL 866_ ENHHA 871_ AAAWN 876_ LFMSR 881_ PEYNF 886_ LINLD 891_ HVEFK 896_ HFRFL 901_ VIEAI 906_ LATDL 911_ KKHFD 916_ FVAKF 921_ NGKVN 926_ DDVGI 931_ DWTNE 936_ NDRLL 941_ VCQMC 946_ IKLAD 951_ INGPA 956_ KCKEL 961_ HLQWT 966_ DGIVN 971_ EFYEQ 976_ GDEEA 981_ SLGLP 986_ ISPFM 991_ DRSAP 996_ QLANL 1001_ QESFI 1006_ SHIVG 1011_ PLCNS 1016_ YDSAG 1021_ LMPGK 1026_ WVEDS 1031_ DESGD 1036_ TDDPE 1041_ EEEEE 1046_ APAPN 1051_ EEETC 1056_ ENNES 1061_ PKKKT 1066_ FKRRK 1071_ IYCQI 1076_ TQHLL 1081_ QNHKM 1086_ WKKVI 1091_ EEEQR 1096_ LAGIE 1101_ NQSLD 1106_ QTPQS 1111_ HSSEQ 1116_ IQAIK 1121_ EEEEE 1126_ KGKPR 1131_ GEEIP 1136_TQKPD
1: Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099)