Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105)
1_MPSAT 6_ SHSGS 11_ GSKSS 16_ GPPPP 21_ SGSSG 26_ SEAAA 31_ GAGAA 36_ APASQ 41_ HPATG 46_ TGAVQ 51_ TEAMK 56_ QILGV 61_ IDKKL 66_ RNLEK 71_ KKGKL 76_ DDYQE 81_ RMNKG 86_ ERLNQ 91_ DQLDA 96_ VSKYQ 101_ EVTNN 106_ LEFAK 111_ ELQRS 116_ FMALS 121_ QDIQK 126_ TIKKT 131_ ARREQ 136_ LMREE 141_ AEQKR 146_ LKTVL 151_ ELQYV 156_ LDKLG 161_ DDEVR 166_ TDLKQ 171_ GLNGV 176_ PILSE 181_ EELSL 186_ LDEFY 191_ KLVDP 196_ ERDMS 201_ LRLNE 206_ QYEHA 211_ SIHLW 216_ DLLEG 221_ KEKPV 226_ CGTTY 231_ KVLKE 236_ IVERV 241_ FQSNY 246_ FDSTH 251_ NHQNG 256_ LCEEE 261_ EAASA 266_ PAVED 271_ QVPEA 276_ EPEPA 281_ EEYTE 286_ QSEVE 291_ STEYV 296_ NRQFM 301_ AETQF 306_ TSGEK 311_ EQVDE 316_ WTVET 321_ VEVVN 326_ SLQQQ 331_ PQAAS 336_ PSVPE 341_ PHSLT 346_ PVAQA 351_ DPLVR 356_ RQRVQ 361_ DLMAQ 366_ MQGPY 371_ NFIQD 376_ SMLDF 381_ ENQTL 386_ DPAIV 391_ SAQPM 396_ NPTQN 401_ MDMPQ 406_ LVCPP 411_ VHSES 416_ RLAQP 421_ NQVPV 426_ QPEAT 431_ QVPLV 436_ SSTSE 441_ GYTAS 446_ QPLYQ 451_ PSHAT 456_ EQRPQ 461_ KEPID 466_ QIQAT 471_ ISLNT 476_ DQTTA 481_ SSSLP 486_ AASQP 491_ QVFQA 496_ GTSKP 501_ LHSSG 506_ INVNA 511_ APFQS 516_ MQTVF 521_ NMNAP 526_ VPPVN 531_ EPETL 536_ KQQNQ 541_ YQASY 546_ NQSFS 551_ SQPHQ 556_ VEQTE 561_ LQQEQ 566_ LQTVV 571_ GTYHG 576_ SPDQS 581_ HQVTG 586_ NHQQP 591_ PQQNT 596_ GFPRS 601_ NQPYY 606_ NSRGV 611_ SRGGS 616_ RGARG 621_ LMNGY 626_ RGPAN 631_ GFRGG 636_ YDGYR 641_ PSFSN 646_ TPNSG 651_ YTQSQ 656_ FSAPR 661_ DYSGY 666_ QRDGY 671_ QQNFK 676_ RGSGQ 681_ SGPRG 686_ APRGR 691_ GGPPR 696_ PNRGM 701_PQMNT
1: mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34074792, PubMed:36040869, PubMed:36279435). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (PubMed:31439799). Binds directly and selectively to MYC and CCND2 mRNAs (PubMed:17210633). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (PubMed:17210633)