Growth factor receptor-bound protein 14 (GRB14 adapter protein)
1_MTTSL 6_ QDGQS 11_ AASRA 16_ AARDS 21_ PLAAQ 26_ VCGAA 31_ QGRGD 36_ AHDLA 41_ PAPWL 46_ HARAL 51_ LPLPD 56_ GTRGC 61_ AADRR 66_ KKKDL 71_ DVPEM 76_ PSIPN 81_ PFPEL 86_ CCSPF 91_ TSVLS 96_ ADLFP 101_ KANSR 106_ KKQVI 111_ KVYSE 116_ DETSR 121_ ALDVP 126_ SDITA 131_ RDVCQ 136_ LLILK 141_ NHYID 146_ DHSWT 151_ LFEHL 156_ PHIGV 161_ ERTIE 166_ DHELV 171_ IEVLS 176_ NWGIE 181_ EENKL 186_ YFRKN 191_ YAKYE 196_ FFKNP 201_ MYFFP 206_ EHMVS 211_ FATET 216_ NGEIS 221_ PTQIL 226_ QMFLS 231_ SSTYP 236_ EIHGF 241_ LHAKE 246_ QGKKS 251_ WKKIY 256_ FFLRR 261_ SGLYF 266_ STKGT 271_ SKEPR 276_ HLQFF 281_ SEFGN 286_ SDIYV 291_ SLAGK 296_ KKHGA 301_ PTNYG 306_ FCFKP 311_ NKAGG 316_ PRDLK 321_ MLCAE 326_ EEQSR 331_ TCWVT 336_ AIRLL 341_ KYGMQ 346_ LYQNY 351_ MHPYQ 356_ GRSGC 361_ SSQSI 366_ SPMRS 371_ ISENS 376_ LVAMD 381_ FSGQK 386_ SRVIE 391_ NPTEA 396_ LSVAV 401_ EEGLA 406_ WRKKG 411_ CLRLG 416_ THGSP 421_ TASSQ 426_ SSATN 431_ MAIHR 436_ SQPWF 441_ HHKIS 446_ RDEAQ 451_ RLIIQ 456_ QGLVD 461_ GVFLV 466_ RDSQS 471_ NPKTF 476_ VLSMS 481_ HGQKI 486_ KHFQI 491_ IPVED 496_ DGEMF 501_ HTLDD 506_ GHTRF 511_ TDLIQ 516_ LVEFY 521_ QLNKG 526_ VLPCK 531_LKHYC
1: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal