Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
1_MELDL 6_ SPPHL 11_ SSSPE 16_ DLCPA 21_ PGTPP 26_ GTPRP 31_ PDTPL 36_ PEEVK 41_ RSQPL 46_ LIPTT 51_ GRKLR 56_ EEERR 61_ ATSLP 66_ SIPNP 71_ FPELC 76_ SPPSQ 81_ SPILG 86_ GPSSA 91_ RGLLP 96_ RDASR 101_ PHVVK 106_ VYSED 111_ GACRS 116_ VEVAA 121_ GATAR 126_ HVCEM 131_ LVQRA 136_ HALSD 141_ ETWGL 146_ VECHP 151_ HLALE 156_ RGLED 161_ HESVV 166_ EVQAA 171_ WPVGG 176_ DSRFV 181_ FRKNF 186_ AKYEL 191_ FKSSP 196_ HSLFP 201_ EKMVS 206_ SCLDA 211_ HTGIS 216_ HEDLI 221_ QNFLN 226_ AGSFP 231_ EIQGF 236_ LQLRG 241_ SGRKL 246_ WKRFF 251_ CFLRR 256_ SGLYY 261_ STKGT 266_ SKDPR 271_ HLQYV 276_ ADVNE 281_ SNVYV 286_ VTQGR 291_ KLYGM 296_ PTDFG 301_ FCVKP 306_ NKLRN 311_ GHKGL 316_ RIFCS 321_ EDEQS 326_ RTCWL 331_ AAFRL 336_ FKYGV 341_ QLYKN 346_ YQQAQ 351_ SRHLH 356_ PSCLG 361_ SPPLR 366_ SASDN 371_ TLVAM 376_ DFSGH 381_ AGRVI 386_ ENPRE 391_ ALSVA 396_ LEEAQ 401_ AWRKK 406_ TNHRL 411_ SLPMP 416_ ASGTS 421_ LSAAI 426_ HRTQL 431_ WFHGR 436_ ISREE 441_ SQRLI 446_ GQQGL 451_ VDGLF 456_ LVRES 461_ QRNPQ 466_ GFVLS 471_ LCHLQ 476_ KVKHY 481_ LILPS 486_ EEEGR 491_ LYFSM 496_ DDGQT 501_ RFTDL 506_ LQLVE 511_ FHQLN 516_ RGILP 521_ CLLRH 526_CCTRV
1: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity)