Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
1_MEGSK 6_ TSNNS 11_ TMQVS 16_ FVCQR 21_ CSQPL 26_ KLDTS 31_ FKILD 36_ RVTIQ 41_ ELTAP 46_ LLTTA 51_ QAKPG 56_ ETQEE 61_ ETNSG 66_ EEPFI 71_ ETPRQ 76_ DGVSR 81_ RFIPP 86_ ARMMS 91_ TESAN 96_ SFTLI 101_ GEASD 106_ GGTME 111_ NLSRR 116_ LKVTG 121_ DLFDI 126_ MSGQT 131_ DVDHP 136_ LCEEC 141_ TDTLL 146_ DQLDT 151_ QLNVT 156_ ENECQ 161_ NYKRC 166_ LEILE 171_ QMNED 176_ DSEQL 181_ QMELK 186_ ELALE 191_ EERLI 196_ QELED 201_ VEKNR 206_ KIVAE 211_ NLEKV 216_ QAEAE 221_ RLDQE 226_ EAQYQ 231_ REYSE 236_ FKRQQ 241_ LELDD 246_ ELKSV 251_ ENQMR 256_ YAQTQ 261_ LDKLK 266_ KTNVF 271_ NATFH 276_ IWHSG 281_ QFGTI 286_ NNFRL 291_ GRLPS 296_ VPVEW 301_ NEINA 306_ AWGQT 311_ VLLLH 316_ ALANK 321_ MGLKF 326_ QRYRL 331_ VPYGN 336_ HSYLE 341_ SLTDK 346_ SKELP 351_ LYCSG 356_ GLRFF 361_ WDNKF 366_ DHAMV 371_ AFLDC 376_ VQQFK 381_ EEVEK 386_ GETRF 391_ CLPYR 396_ MDVEK 401_ GKIED 406_ TGGSG 411_ GSYSI 416_ KTQFN 421_ SEEQW 426_ TKALK 431_ FMLTN 436_ LKWGL 441_AWVSS
1: Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:25484083, PubMed:28445460, PubMed:37776275). Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123, PubMed:23974797, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). May play a role in antiviral host defense
2: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors
3: (Microbial infection) Protects against infection by a neurovirulent strain of Sindbis virus