Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL)
1_MPADI 6_ MEKNS 11_ SSPVA 16_ ATPAS 21_ VNTTP 26_ DKPKT 31_ ASEHR 36_ KSSKP 41_ IMEKR 46_ RRARI 51_ NESLS 56_ QLKTL 61_ ILDAL 66_ KKDSS 71_ RHSKL 76_ EKADI 81_ LEMTV 86_ KHLRN 91_ LQRAQ 96_ MTAAL 101_ STDPS 106_ VLGKY 111_ RAGFS 116_ ECMNE 121_ VTRFL 126_ STCEG 131_ VNTEV 136_ RTRLL 141_ GHLAN 146_ CMTQI 151_ NAMTY 156_ PGQPH 161_ PALQA 166_ PPPPP 171_ PGPGG 176_ PQHAP 181_ FAPPP 186_ PLVPI 191_ PGGAA 196_ PPPGG 201_ APCKL 206_ GSQAG 211_ EAAKV 216_ FGGFQ 221_ VVPAP 226_ DGQFA 231_ FLIPN 236_ GAFAH 241_ SGPVI 246_ PVYTS 251_ NSGTS 256_ VGPNA 261_ VSPSS 266_ GPSLT 271_ADSMW
1: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage