Histone RNA hairpin-binding protein (Histone stem-loop-binding protein)
1_MACRP 6_ RSPPR 11_ HQSRC 16_ DGDAS 21_ PPSPA 26_ RWSLG 31_ RKRRA 36_ DGRRW 41_ RPEDA 46_ EEAEH 51_ RGAER 56_ RPESF 61_ TTPEG 66_ PKPRS 71_ RCSDW 76_ ASAVE 81_ EDEMR 86_ TRVNK 91_ EMARY 96_ KRKLL 101_ INDFG 106_ RERKS 111_ SSGSS 116_ DSKES 121_ MSTVP 126_ ADFET 131_ DESVL 136_ MRRQK 141_ QINYG 146_ KNTIA 151_ YDRYI 156_ KEVPR 161_ HLRQP 166_ GIHPK 171_ TPNKF 176_ KKYSR 181_ RSWDQ 186_ QIKLW 191_ KVALH 196_ FWDPP 201_ AEEGC 206_ DLQEI 211_ HPVDL 216_ ESAES 221_ SSEPQ 226_ TSSQD 231_ DFDVY 236_ SGTPT 241_ KVRHM 246_ DSQVE 251_ DEFDL 256_ EACLT 261_EPLRD
1: RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity)