ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Inward rectifier K(+) channel Kir2.2v) (Potassium channel, inwardly rectifying subfamily J member 12)
1_MTAAS 6_ RANPY 11_ SIVSS 16_ EEDGL 21_ HLVTM 26_ SGANG 31_ FGNGK 36_ VHTRR 41_ RCRNR 46_ FVKKN 51_ GQCNI 56_ EFANM 61_ DEKSQ 66_ RYLAD 71_ MFTTC 76_ VDIRW 81_ RYMLL 86_ IFSLA 91_ FLASW 96_ LLFGI 101_ IFWVI 106_ AVAHG 111_ DLEPA 116_ EGRGR 121_ TPCVM 126_ QVHGF 131_ MAAFL 136_ FSIET 141_ QTTIG 146_ YGLRC 151_ VTEEC 156_ PVAVF 161_ MVVAQ 166_ SIVGC 171_ IIDSF 176_ MIGAI 181_ MAKMA 186_ RPKKR 191_ AQTLL 196_ FSHNA 201_ VVALR 206_ DGKLC 211_ LMWRV 216_ GNLRK 221_ SHIVE 226_ AHVRA 231_ QLIKP 236_ RVTEE 241_ GEYIP 246_ LDQID 251_ IDVGF 256_ DKGLD 261_ RIFLV 266_ SPITI 271_ LHEID 276_ EASPL 281_ FGISR 286_ QDLET 291_ DDFEI 296_ VVILE 301_ GMVEA 306_ TAMTT 311_ QARSS 316_ YLANE 321_ ILWGH 326_ RFEPV 331_ LFEEK 336_ NQYKI 341_ DYSHF 346_ HKTYE 351_ VPSTP 356_ RCSAK 361_ DLVEN 366_ KFLLP 371_ SANSF 376_ CYENE 381_ LAFLS 386_ RDEED 391_ EADGD 396_ QDGRS 401_ RDGLS 406_ PQARH 411_ DFDRL 416_ QAGGG 421_ VLEQR 426_PYRRE
1: Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium