Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]
1_MKYKN 6_ LMARA 11_ LYDNV 16_ PECAE 21_ ELAFR 26_ KGDIL 31_ TVIEQ 36_ NTGGL 41_ EGWWL 46_ CSLHG 51_ RQGIV 56_ PGNRV 61_ KLLIG 66_ PMQET 71_ ASSHE 76_ QPASG 81_ LMQQT 86_ FGQQK 91_ LYQVP 96_ NPQAA 101_ PRDTI 106_ YQVPP 111_ SYQNQ 116_ GIYQV 121_ PTGHG 126_ TQEQE 131_ VYQVP 136_ PSVQR 141_ SIGGT 146_ SGPHV 151_ GKKVI 156_ TPVRT 161_ GHGYV 166_ YEYPS 171_ RYQKD 176_ VYDIP 181_ PSHTT 186_ QGVYD 191_ IPPSS 196_ AKGPV 201_ FSVPV 206_ GEIKP 211_ QGVYD 216_ IPPTK 221_ GVYAI 226_ PPSAC 231_ RDEAG 236_ LREKD 241_ YDFPP 246_ PMRQA 251_ GRPDL 256_ RPEGV 261_ YDIPP 266_ TCTKP 271_ AGKDL 276_ HVKYN 281_ CDIPG 286_ AAEPV 291_ ARRHQ 296_ SLSPN 301_ HPPPQ 306_ LGQSV 311_ GSQND 316_ AYDVP 321_ RGVQF 326_ LEPPA 331_ ETSEK 336_ ANPQE 341_ RDGVY 346_ DVPLH 351_ NPPDA 356_ KGSRD 361_ LVDGI 366_ NRLSF 371_ SSTGS 376_ TRSNM 381_ STSST 386_ SSKES 391_ SLSAS 396_ PAQDK 401_ RLFLD 406_ PDTAI 411_ ERLQR 416_ LQQAL 421_ EMGVS 426_ SLMAL 431_ VTTDW 436_ RCYGY 441_ MERHI 446_ NEIRT 451_ AVDKV 456_ ELFLK 461_ EYLHF 466_ VKGAV 471_ ANAAC 476_ LPELI 481_ LHNKM 486_ KRELQ 491_ RVEDS 496_ HQILS 501_ QTSHD 506_ LNECS 511_ WSLNI 516_ LAINK 521_ PQNKC 526_ DDLDR 531_ FVMVA 536_ KTVPD 541_ DAKQL 546_ TTTIN 551_ TNAEA 556_ LFRPG 561_ PGSLH 566_ LKNGP 571_ ESIMN 576_ STEYP 581_ HGGSQ 586_ GQLLH 591_ PGDHK 596_ AQAHN 601_ KALPP 606_ GLSKE 611_ QAPDC 616_ SSSDG 621_ SERSW 626_ MDDYD 631_ YVHLQ 636_ GKEEF 641_ ERQQK 646_ ELLEK 651_ ENIMK 656_ QNKMQ 661_ LEHHQ 666_ LSQFQ 671_ LLEQE 676_ ITKPV 681_ ENDIS 686_ KWKPS 691_ QSLPT 696_ TNSGV 701_ SAQDR 706_ QLLCF 711_ YYDQC 716_ ETHFI 721_ SLLNA 726_ IDALF 731_ SCVSS 736_ AQPPR 741_ IFVAH 746_ SKFVI 751_ LSAHK 756_ LVFIG 761_ DTLTR 766_ QVTAQ 771_ DIRNK 776_ VMNSS 781_ NQLCE 786_ QLKTI 791_ VMATK 796_ MAALH 801_ YPSTT 806_ ALQEM 811_ VHQVT 816_ DLSRN 821_ AQLFK 826_RSLLE
1: Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity)